PedAM
Pediatric Disease Annotations & Medicines
| Disease | hypercalcemia |
| Phenotype | C0036202|sarcoid |
| Sentences | 2 |
| PubMedID- 24663253 | hypercalcemia in sarcoidosis is due to three mechanistic reasons: (1) systemic conversion of 25-hydroxyvitamin d to 1,25-dihydroxyvitamin d by the enzyme 1-alpha hydroxylase produced by activated monocyte/macrophage system, (2) production of parathormone-related peptide (pthrp) by the sarcoid granuloma, (3) tissue-level conversion of 25-hydroxyvitamin d to 1,25-dihydroxyvitamin d by 1-alphahydroxylase produced by local monocyte/macrophage system in the sarcoid granuloma. |
| PubMedID- 21873732 | The mechanism of hypercalcaemia in sarcoidosis is poorly understood but is thought to involve parathyroid hormone-independent 1-hydroxylation of 25-hydroxyvitamin d within sarcoid lesions. |
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