PedAM
Pediatric Disease Annotations & Medicines
| Disease | hiv infections |
| Phenotype | C0276548|hiv encephalitis |
| Sentences | 2 |
| PubMedID- 22315702 | Following hiv infection, especially with hiv encephalitis, variable degree of demyelination is found in the brain, especially the subcortical white matter of the frontal and temporal lobes. |
| PubMedID- 25890304 | As de novo igf2r expression occurs in human microglia in hiv encephalitis (a model of tissue macrophages hiv infection) and igf2r is a cellular cofactor for hiv replication [46], our biomarker data supports that igf2r (likely induced by inflammatory mediators) boosts hiv replication (hence detectable vl) and induces cd4+ t cell depletion. |
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