PedAM
Pediatric Disease Annotations & Medicines
| Disease | hemophilia a |
| Phenotype | C0022408|arthropathy |
| Sentences | 7 |
| PubMedID- 21255253 | Conclusion: this randomized trial confirms the efficacy of prophylaxis in preventing bleeds and arthropathy in children with hemophilia, particularly when it is initiated early in life. |
| PubMedID- 26366108 | While early treatment was good, it was demonstrated in sweden that routine infusion of clotting factor in the non-bleeding state could actually prevent spontaneous bleeding and the severe joint damage that was caused by repetitive bleeding into joints.5 this process of “primary prophylaxis” was rapidly adopted for younger patients with remarkable reductions in secondary arthropathy due to hemarthrosis.6 specialized hemophilia treatment centers came into existence, further enhancing and standardizing the care of hemophilia and providing routine access to orthopedic surgeons, physiotherapists, dentists, dieticians, and social workers. |
| PubMedID- 19943875 | Background: prophylactic factor (f)viii has been shown to reduce bleeds and arthropathy in patients with severe hemophilia a. |
| PubMedID- 21922352 | To prevent joint bleedings and thus arthropathy in patients with severe hemophilia, prophylactic treatment with clotting factor concentrate is mostly indicated [13]. |
| PubMedID- 24022804 | arthropathy in patients with moderate hemophilia a: a systematic review of the literature. |
| PubMedID- 22778972 | This randomized trial confirmed the efficacy of prophylaxis in preventing bleeds and arthropathy in children with hemophilia, particularly when it is initiated early in life. |
| PubMedID- 23906463 | [long-term low-dose secondary prophylaxis for severe and moderate hemophilia children with arthropathy in china: a single-center observation study]. |
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