PedAM
Pediatric Disease Annotations & Medicines
| Disease | heart disease |
| Phenotype | C0020445|familial hypercholesterolemia |
| Sentences | 2 |
| PubMedID- 23698400 | Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase (hmgcr), a limiting step of cholesterol synthesis, and are widely used to modulate cholesterol levels in patients at risk of heart disease, or with familial hypercholesterolemia. |
| PubMedID- 22010136 | Mirroring these results, the apolipoprotein e4/e4 genotype was also associated with lower coronary heart disease risk in patients with familial hypercholesterolemia with an ldlr mutation (hazard ratio, 0.26; hazard ratio, 0.08-0.80; p=0.02). |
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