PedAM
Pediatric Disease Annotations & Medicines
| Disease | graft-vs-host disease |
| Phenotype | C0085669|acute leukemia |
| Sentences | 4 |
| PubMedID- 24018394 | Prediction of subsequent leukemia-free survival (lfs) and chronic graft-versus-host disease (gvhd) in adults with acute leukemia who survived at least 1 year after allogeneic hematopoietic cell transplantation is difficult. |
| PubMedID- 26039207 | Recent trials indicate that high doses of cd34+ progenitors from g-csf mobilized peripheral blood leukocytes isolated and t-cell depleted by immunoadsorption to paramagnetic beads, when administered after myeloablative conditioning with tbi and chemotherapy or chemotherapy alone can secure consistent engraftment and abrogate gvhd in patients with acute leukemia without incurring an increased risk of a recurrent leukemia. |
| PubMedID- 21188220 | Especially in acute leukemias, occurrence of mild acute gvhd grade i-ii and chronic gvhd confers the best antileukemic effect. |
| PubMedID- 26039200 | Clinical trials have shown that a strategy for haploidentical transplantation based on the infusion of high numbers of t-cell-depleted hematopoietic progenitor cells and no post-transplant immunosuppression controls graft rejection and gvhd in patients with acute leukemia. |
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