PedAM
Pediatric Disease Annotations & Medicines
| Disease | gonadoblastoma |
| Phenotype | C0018051|gonadal dysgenesis |
| Sentences | 4 |
| PubMedID- 23824832 | The significant percentage of gonadoblastoma in patients with 46,xy complete gonadal dysgenesis due to partial 9p monosomy also continues to support the necessity of gonadectomy in this patient population. |
| PubMedID- 20981291 | [49], a 9-month-old infant with hypertrophic clitoris and separated urethral and vaginal opening was diagnosed as having 46,xy incomplete “pure gonadal dysgenesis.” examination of both gonads revealed gonadoblastoma and bilateral salpingo-gonadectomy; partial hysterectomy was performed.fallat and donahoe [50] note that the gonads most at risk for malignant transformation are both dysgenetic and intraabdominal and that early gonadectomies are recommended, as malignancies have been reported in infancy. |
| PubMedID- 22906432 | We present two cases of gonadoblastoma associated with complete gonadal dysgenesis and turner syndrome, respectively, with dysgerminoma overgrowth found in one case. |
| PubMedID- 26089923 | 1gonadoblastoma arising within gonadal dysgenesis: a gonadoblastoma with large germ cells with vesicular nuclei, prominent nucleoli and abundant cytoplasm and hyaline globules infiltrating adjacent gonad (h&e stain); b nuclear immunoreactivity with oct3/4; c cd117 (c-kit) cytoplasmic immunoreactivity; d placental alkaline phosphatase (plap) cytoplasmic immunoreactivityfig. |
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