PedAM

Pediatric Disease Annotations & Medicines

Disease	glioblastoma
Phenotype	C0004114\|astrocytoma
Sentences	6
PubMedID- 21663411	Perivascularly, cd68-positive infiltrate was also more prevalent in glioblastoma when compared with pilocytic astrocytoma (97% vs 86%, respectively; p = 0.0003).
PubMedID- 21193945	In contrast to pilocytic astrocytoma, evaluation of the pediatric glioblastoma expression dataset [11] showed minimal expression of omg (mean expression measure = 416.2(81.3)).1 however, olig2, olig1, and gfap were highly expressed in pediatric glioblastoma (mean expression measures 1085.9 (117.1), 2609.4 (426.5), 5499.8 (731), respectively) (see footnote 1).table 7differential expression of neural lineage genesgene namegenbank #diff exp in olig2 null (y/n) mean expm-ep (st.
PubMedID- 20860896	The resected tumor showed histological features of a glioblastoma with granular cell astrocytoma features, lacking amplification of the egfr gene region and idh1r132h mutation.
PubMedID- 21804458	Only secondary glioblastomas (arising from low grade astrocytoma) were positive for c-erbb-2 protein, and all of the primary (arising “de novo”) glioblastoma were negative for c-erbb-2 protein.
PubMedID- 23349846	Previously, kato et al (2008) demonstrated that the transcripts of sulfotransferases including ksgal6st, glcnac6st-1, and glcnac6st-5, that are responsible for sulfation of kertan sulfate (ks), are significantly up-regulated in glioblastoma compared with diffuse astrocytoma and anaplastic astrocytoma isolated from brain tumor patients using quantitative pcr analysis, suggesting the association of ks with progression of astrocytic tumors [26].
PubMedID- 21674016	astrocytomas represent 75% of all gliomas, and glioblastomas form 51.7% of cases.1 glioblastoma is the most frequent and malignant astrocytoma, and despite advances in diagnosis and treatment of these tumors, their prognosis remains dismal.4,5 the development of new effective therapies is urgently needed.

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