PedAM
Pediatric Disease Annotations & Medicines
| Disease | gastroesophageal reflux disease |
| Phenotype | C0279628|oesophageal adenocarcinoma |
| Sentences | 4 |
| PubMedID- 23180455 | oesophageal adenocarcinoma is associated with gastro-oesophageal reflux disease, obesity and the precursor lesion barrett's oesophagus; its incidence has increased faster than that of any other cancer in the usa in the past few decades.2 oesophageal squamous cell carcinoma is associated with tobacco smoking, alcohol consumption and poor nutrition; its incidence remains much higher than that of oesophageal adenocarcinoma in most of the world.3 patients with oesophageal cancer continue to have a poor prognosis, with 5-year overall survival still less than 15%.4 a greater understanding of the molecular basis of oesophageal cancer, including the development of new biomarkers, is greatly needed to improve the diagnosis, prognosis and treatment of patients with this disease. |
| PubMedID- 26519754 | The incidence of oesophageal adenocarcinoma (oac), arising from reflux-induced barrett oesophagus (bo), is increasing dramatically. |
| PubMedID- 24243140 | Siewert and leers have previously reported 37% 2 and 50% 3 respectively from large single centre western series compared to the low prevalence of type iii tumours seen in eastern series (5.6%) 29. the proportional increase in type i tumours in our series is likely to represent the widely reported increase in incidence of oesophageal adenocarcinoma 30,31 associated with gastro-oesophageal reflux disease 32 and barrett's metaplasia 33 in the united kingdom 34. the expansion of endoscopic barrett's surveillance strategies is also likely to have increased disease detection and treatment. |
| PubMedID- 20955441 | Meta-analysis: the association of oesophageal adenocarcinoma with symptoms of gastro-oesophageal reflux. |
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