PedAM
Pediatric Disease Annotations & Medicines
| Disease | gastroesophageal reflux disease |
| Phenotype | C0004096|asthma |
| Sentences | 39 |
| PubMedID- 22448100 | (1,2) the prevalance of gastroesophageal reflux disease (gerd) in asthma patients was 42% to 69% according to the questionnaire for the diagnosis of reflux disease (quest). |
| PubMedID- 25510089 | The prevalence of gastroesophageal reflux disease in patients with asthma ranged from 33 to 90%. |
| PubMedID- 21211369 | Objective: to evaluate the effect of antireflux treatment in asthma patients with gastroesophageal reflux disease (gerd). |
| PubMedID- 20827103 | Increased risk of concurrent asthma among patients with gastroesophageal reflux disease: a nationwide population-based study. |
| PubMedID- 22931117 | Association of gastroesophageal reflux disease with asthma control. |
| PubMedID- 24250694 | [28] in another study by littner et al., it was shown that in patients with moderate to severe persistent asthma and symptoms of acid reflux, treatment with lansoprazole did not improve asthma symptoms or pulmonary function, or reduce albuterol use. |
| PubMedID- 22594096 | Objective: to assess the effectiveness and safety of traditional chinese medicine (tcm) treatment of non-acute bronchial asthma complicated by gastroesophageal reflux. |
| PubMedID- 23166570 | gastroesophageal reflux disease (gerd) is widely associated with asthma, chronic cough, and laryngitis. |
| PubMedID- 22253635 | Because of the high incidence of gastro-esophageal reflux (gerd) in patients with asthma [12], the complex relationship between them, and finally the difficulty of diagnosing gerd among asthmatic patients we designed this study. |
| PubMedID- 19817951 | Prevalence of gastroesophageal reflux disease in patients with asthma and chronic obstructive pulmonary disease. |
| PubMedID- 21786581 | Combination of bronchial asthma (ba) with gastroesophageal reflux disease (grd) is now most prevalent among combined pathology of the respiratory and gastrointestinal tracts. |
| PubMedID- 21167571 | Extrathoracic airway receptors might be involved in all 3 conditions because asthma is often associated with pr/crs and gastroesophageal refluxate might reach the upper airway. |
| PubMedID- 23277872 | However, those diseases should also be evaluated considering the strong association of gerd with asthma and the possible clinical impact of coronary heart disease on asthmatics. |
| PubMedID- 22081767 | Co-existence of gerd with asthma or cva is fairly common, and cough may subside with anti-reflux medications [24]. |
| PubMedID- 21427926 | [clinical and instrumental characteristics of the gastroesophageal reflux in children with bronchial asthma, possibilities of therapy]. |
| PubMedID- 23244779 | Chronic cough, chronic laryngitis and asthma are significantly associated with gerd [5].there is a cause and effect relationship between asthma and gastroesophageal reflux which can turn into a vicious cycle. |
| PubMedID- 24455432 | A recent study [80] by means of multivariate logistic regression analyses revealed the independent association of gerd with not well-controlled asthma (odds ratio, 3.12; 95% confidence interval, 1.53–4.88) after other established contributors to asthma control were adjusted. |
| PubMedID- 22045347 | A large trial concluded that esomeprazole did not improve asthma control even with comorbid acid reflux, questioning the importance of acid reflux in asthma. |
| PubMedID- 22135740 | Oesophageal acid in the distal oesophagus stimulates airway irritation and an inflammatory response, with the release of potent mediators of bronchoconstriction [25], which are associated with coughing and reflux-induced bronchoconstriction in patients with asthma [21]. |
| PubMedID- 21819338 | reflux was not associated with measures of asthma control in obese patients. |
| PubMedID- 23922836 | Presence of asthma is associated with gerd, [34], [35], and recent studies indicate an increased prevalence of gerd symptoms in patients with copd [36]–[38]. |
| PubMedID- 22980911 | However the prevalence of asymptomatic acid reflux in patients with asthma varies between 10% and 62% according to the underlying severity of the asthma and the measure used to identify symptoms [15]. |
| PubMedID- 23018910 | Nocturnal gastro-oesophageal reflux (ngor) is associated with asthma and obstructive sleep apnoea (osa). |
| PubMedID- 22615884 | Thus while recent clinical trials of proton pump inhibitors for gastroesophageal reflux for subjects with asthma have failed to result in clinically significant changes in asthma control [57], [58], gastroesophageal reflux remains a common co-morbid condition in subjects with asthma and is therefore frequently controlled for in other asthma association studies [59]. |
| PubMedID- 22274684 | Design, setting, and participants: the study of acid reflux in children with asthma, a randomized, masked, placebo-controlled, parallel clinical trial that compared lansoprazole with placebo in children with poor asthma control who were receiving inhaled corticosteroid treatment. |
| PubMedID- 23049590 | We excluded patients who had significant pulmonary disease other than asthma or a history of gastroesophageal reflux. |
| PubMedID- 24816214 | Reported that 56.7% of patients with difficult-to-control asthma were diagnosed with gerd [45,48]. |
| PubMedID- 26289993 | The rest of types and subtypes of respiratory viruses and comorbidities such as gastroesophageal reflux were not associated with asthma either in the univariate analysis or in the adjusted analysis (data not shown). |
| PubMedID- 20843346 | Whether the finding that more severe forms of asthma were associated with more reflux symptoms was due to reflux aggravating asthma or severe bronchospasm promoting reflux could not be determined. |
| PubMedID- 21496295 | The documented association of the clinical picture of gerd with asthma and vice versa can be explained at least partly in some cases on basis of undiagnosed atopic ee associated with atopic asthma. |
| PubMedID- 23197288 | However, there is no conclusive evidence per se that asymptomatic gerd informs asthma control, and treatment of gerd in the few controlled trials available for review does not substantively improve asthma outcomes. |
| PubMedID- 21785566 | Changes in estrogen and progesterone are thought to improve the disease while elevation of the diaphragm, increased pulmonary vascular permeability, and increased gastroesophageal reflux have been associated with worsening asthma [49]. |
| PubMedID- 21049219 | The prevalence of gerd is higher in patients with asthma than in the general population, and gerd is associated with difficult‐to‐control asthma. |
| PubMedID- 24202552 | Background: patients with refractory asthma frequently have elements of laryngopharyngeal reflux (lpr) with potential aspiration contributing to their poor control. |
| PubMedID- 22826054 | We conclude that the prevalence of laryngopharyngeal reflux in children with difficult-to-treat asthma is substantial. |
| PubMedID- 25859274 | Who found that gerd was not associated with worse asthma control in obese patients [34]. |
| PubMedID- 20351959 | [17] on the other hand, in asthma patients with gerd, there is an evidence of autonomic dysfunction with primarily hyper-vagal responsiveness. |
| PubMedID- 24714277 | An older study by kiljander et al found that in asthmatic patients with documented gerd by 24-h ph monitoring, there was a reduction in nocturnal asthma symptoms, whereas daytime asthma outcome did not improve after an 8-week omeprazole treatment [60]. |
| PubMedID- 25808429 | In the multiple regression adjusted for age, gender, bmi, tobacco smoke, and asthma, those with nocturnal gerd in 1999 (>/=3 episodes of nocturnal gastroesophageal reflux symptoms per week) had an or of 1.6 (95% ci 1.0-2.5, p = 0.03) to develop nir in 2010. |
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