PedAM
Pediatric Disease Annotations & Medicines
| Disease | esophageal cancer |
| Phenotype | C0022584|tylosis |
| Sentences | 4 |
| PubMedID- 26419362 | Oesophageal cancer associated with tylosis usually presents in middle to late life (from mid-fifties onwards) and shows no earlier development than the sporadic form of the disease. |
| PubMedID- 22359545 | Cytoglobin is a candidate for the tylosis with oesophageal cancer gene, and its expression is strongly down-regulated in non-cancerous oesophageal biopsies from patients with toc compared with normal biopsies. |
| PubMedID- 22638770 | tylosis with esophageal cancer (toc) is a rare familial cancer syndrome inherited in an autosomal-dominant manner and characterized by esophageal cancer susceptibility and hyperkeratotic skin lesions. |
| PubMedID- 24738885 | In contrast, the dominantly inherited tylosis with oesophageal cancer appears to result from gain-of-function in adam17 due to increased processing via irhom2. |
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