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PedAM

Pediatric Disease Annotations & Medicines




Disease esophageal cancer
Phenotype C0022584|tylosis
Sentences 4
PubMedID- 26419362 Oesophageal cancer associated with tylosis usually presents in middle to late life (from mid-fifties onwards) and shows no earlier development than the sporadic form of the disease.
PubMedID- 22359545 Cytoglobin is a candidate for the tylosis with oesophageal cancer gene, and its expression is strongly down-regulated in non-cancerous oesophageal biopsies from patients with toc compared with normal biopsies.
PubMedID- 22638770 tylosis with esophageal cancer (toc) is a rare familial cancer syndrome inherited in an autosomal-dominant manner and characterized by esophageal cancer susceptibility and hyperkeratotic skin lesions.
PubMedID- 24738885 In contrast, the dominantly inherited tylosis with oesophageal cancer appears to result from gain-of-function in adam17 due to increased processing via irhom2.

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