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PedAM

Pediatric Disease Annotations & Medicines




Disease epilepsy
Phenotype C0042373|vascular disease
Sentences 6
PubMedID- 20586732 Objectives: the aim of the study was to investigate risk factors for cardiovascular disease in patients with epilepsy using the new antiepileptic drug levetiracetam (lev), compared with patients taking carbamazepine (cbz) or lamotrigine (ltg).
PubMedID- 25028247 Purpose: epilepsy is associated with increased cardiovascular disease (cvd) morbidity and mortality.
PubMedID- 25902783 Further, vitamin d deficiency has been demonstrated to be an important regulator in the neurocardiovascular disease pathways associated with epilepsy (scorza et al.
PubMedID- 25503082 Additional exclusion criteria common to both studies included significant pulmonary, gastrointestinal, metabolic (except diabetes mellitus), neurological, psychiatric or other disorders that could affect efficacy or safety assessments or compromise patient safety; significant cardiac or vascular disease; a history of seizure disorder or epilepsy; a history of mild or moderate traumatic brain injury, stroke, transient ischaemic attack or brain neoplasm within 1 year; a history of severe traumatic brain injury within 15 years; a history of malignancy within the past 2 years (except for successfully treated basal cell carcinoma); severe renal impairment; moderate or severe hepatic impairment; chronic hepatitis b or c; active hepatitis b or c within the past 3 months; severe or extensive diabetic foot ulcers, limb amputation, or charcot neuroarthropathy; a clinically relevant history of sensitivity to acetaminophen or opioid analgesics (or their ingredients); any scheduled surgery or painful procedure during the study that could affect efficacy or safety assessments; and any condition (other than painful dpn) that could confound the assessment or self-evaluation of pain (e.g.
PubMedID- 24273498 This association may just suggest epilepsy with concurrent cardiovascular disease, but in this young age group, it may suggest a link between the two conditions, particularly a predisposition for vasovagal hyperactivity.
PubMedID- 23143721 Predictors of epilepsy in children with cerebrovascular disease.

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