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PedAM

Pediatric Disease Annotations & Medicines




Disease epilepsy
Phenotype C0041696|major depression
Sentences 2
PubMedID- 25889039 We have previously reported neuropathological alterations in mesial temporal lobe epilepsy (mtle) patients with major depression and psychosis that suggest a morphological and neurochemical basis for psychopathological symptoms.
PubMedID- 25667841 Eighth, in the context of multiple potential risk factors for the development of de novo major depression with suicide attempt (epilepsy, treatment with aed, lev titration, past alcohol dependence, traumatic brain injury with intracranial hemorrhage, basal ganglia and thalamic lacunar infarcts, and potential genetic predisposition), the probability of lev titration inducing the de novo major depression with associated near fatal suicide attempt was determined by the naranjo's adverse reaction probability scale as probable (scored as 5) [30].

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