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PedAM

Pediatric Disease Annotations & Medicines




Disease encephalopathy
Phenotype C0039841|thiamine deficiency
Sentences 3
PubMedID- 23347747 thiamine deficiency can lead to wernicke's encephalopathy (we), an acute neurological disorder characterized by the clinical triad of oculomotor abnormalities, cerebellar dysfunction, and altered mental state and by the traditionally defined pathology of neuronal loss and hemorrhagic lesions in the paraventricular and periaqueductal grey matter.
PubMedID- 21130821 Emerging evidence suggests that thiamine deficiency (td), the cause of wernicke's encephalopathy, produces alterations in brain function and structural damage that closely model a number of maladies in which neurodegeneration is a characteristic feature, including alzheimer's disease, amyotrophic lateral sclerosis, parkinson's disease, multiple sclerosis, along with alcoholic brain disease, stroke, and traumatic brain injury.
PubMedID- 24078061 thiamine deficiency (td) leads to wernicke's encephalopathy (we), in which focal histological lesions occur in periventricular areas of the brain.

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