PedAM
Pediatric Disease Annotations & Medicines
| Disease | down syndrome |
| Phenotype | C0497327|dementia |
| Sentences | 19 |
| PubMedID- 26483832 | Cognitive rehabilitation of dementia in adults with down syndrome: a review of non-pharmacological interventions. |
| PubMedID- 25594074 | The purpose of this mini review is to provide an updated assessment on apolipoprotein e4 status and risk potential of developing dementia and mortality associated with down syndrome. |
| PubMedID- 21041786 | Change in plasma ass peptides and onset of dementia in adults with down syndrome. |
| PubMedID- 23902161 | A prospective 14-year longitudinal follow-up of dementia in persons with down syndrome. |
| PubMedID- 23601808 | As dementia in people with down syndrome is relatively understudied, we make all of these data publicly available to encourage further analyses of the problem of alzheimer's disease in down syndrome. |
| PubMedID- 25720405 | Mtrnr2l12: a candidate blood marker of early alzheimer's disease-like dementia in adults with down syndrome. |
| PubMedID- 20367747 | Background: the latter stages of dementia in individuals with down syndrome are well documented; however, earlier cognitive and behavioural changes have only recently been described. |
| PubMedID- 24406638 | Recent research has tended to focus on dementia in down syndrome. |
| PubMedID- 21739598 | There is a paucity of treatment trials for dementia in down syndrome in comparison to alzheimer disease in the general (non-down syndrome) population. |
| PubMedID- 21542885 | The clinical and scientific study of dementia in adults with down syndrome led to the development of the amyloid hypothesis as a fundamental concept in alzheimer's disease pathogenesis. |
| PubMedID- 25551263 | Variability of the aging process in dementia-free adults with down syndrome. |
| PubMedID- 26343344 | Behavioural and psychological symptoms of dementia in down syndrome: early indicators of clinical alzheimer's disease. |
| PubMedID- 20597723 | Improvements in understanding the progression of dementia in individuals with down syndrome may lead to improved diagnosis and treatment. |
| PubMedID- 23400708 | Apoe4 is a major genetic risk factor for alzheimer disease and is associated with dementia in down syndrome and poor neurological outcome after traumatic brain injury, cerebral hemorrhage, and other neuropathological disorders. |
| PubMedID- 26288825 | These findings suggest a protective role of mtrnr2l12 in the development of early alzheimer's disease-like dementia in adults with down syndrome. |
| PubMedID- 25735452 | down syndrome (ds) patients with early-onset dementia share similar neurodegenerative features with alzheimer's disease (ad). |
| PubMedID- 25363568 | The presentation of dementia in down syndrome differs compared with typical alzheimer's disease. |
| PubMedID- 22888254 | down syndrome patients with dementia also show loss of memory, cognitive decline, changes in adaptive behavior, neurological changes, and language difficulties;25,26 these symptoms are progressive (not reversible).27 in contrast, the clinical features of individuals with acute neuropsychiatric disorders appear to be more similar to those of individuals with psychiatric illnesses, such as major depressive and obsessive-compulsive disorder or schizophrenia (table 1). |
| PubMedID- 24885175 | Interestingly, down syndrome patients with ad dementia also have an increase in mtdna mutations[9]. |
Page: 1