PedAM
Pediatric Disease Annotations & Medicines
| Disease | dilated cardiomyopathy |
| Phenotype | C0004153|atherosclerosis |
| Sentences | 1 |
| PubMedID- 20434371 | Given that characteristics of dilated cardiomyopathy closely associate with atherosclerosis and are mediated by an imbalance between matrix metalloproteinases (mmps) and timps, we hypothesized that parp-1 gene deletion may protect against hf-induced cardiac hypertrophy and dilatations by altering mp-2/mmps balance in favor of a maintenance of tissue homeostasis. |
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