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PedAM

Pediatric Disease Annotations & Medicines




Disease diarrhea
Phenotype C0024586|carcinoid syndrome
Sentences 10
PubMedID- 25636046 Context: carcinoid syndrome (cs) is associated with elevated serotonin, diarrhea, flushing, and increased risk of valvular heart disease.
PubMedID- 22518322 Small bowel carcinoids, for example, produce serotonin giving rise to the classical carcinoid syndrome with flushing, diarrhea, right-sided heart disease and asthma.
PubMedID- 25012985 We assessed the safety and efficacy of telotristat etiprate, an oral serotonin synthesis inhibitor, in patients with diarrhea associated with carcinoid syndrome.
PubMedID- 23781318 Small intestinal nets often produce vasoactive substances that may result in the carcinoid syndrome, symptoms of which include flushing, diarrhea, carcinoid heart disease, and bronchospasm.
PubMedID- 22253554 Most notably, this may lead to the carcinoid syndrome which consists of flushing, diarrhea, and other symptoms including wheezing and cardiac symptoms.5,6 somatostatin is an endogenous 14 amino acid peptide which binds to somatostatin receptors and has a predominately inhibitory effect on the release of many gastrointestinal hormones.7 the clinical utility of utilizing somatostatin is limited by the short half-life of this peptide in the circulation (less than three minutes).
PubMedID- 25889934 Only one patient had symptoms of carcinoid syndrome with spurious diarrhea and flushing.
PubMedID- 24714698 By this mechanism, somatostatin analogs prevent spontaneous and provoked flushing and secretory diarrhea in patients with carcinoid syndrome.
PubMedID- 25323816 The case highlights the importance of considering functional nets, especially carcinoid syndrome, in patients with chronic unresolving diarrhea, since early diagnosis allows for further treatment options that can prolong survival.
PubMedID- 21678105 The classical carcinoid syndrome with flush, diarrhea and cardiac strain is observed only in 20-30% of patients.
PubMedID- 23118529 The classical carcinoid syndrome, with flushing, diarrhea, and right-sided valvular heart disease, is caused by secretion of serotonin from a metastatic ileal carcinoid tumor.

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