PedAM
Pediatric Disease Annotations & Medicines
| Disease | diabetes mellitus, insulin-dependent |
| Phenotype | C0024266|lymphocytic choriomeningitis |
| Sentences | 2 |
| PubMedID- 23894189 | Our previous studies conducted in a murine model of type 1 diabetes with lymphocytic choriomeningitis virus infection revealed that inkt cells could promote systemic antiviral cd8 t-cell responses while inhibiting deleterious anti-islet t-cell responses, thereby preventing type 1 diabetes (24,25). |
| PubMedID- 24478396 | (30) showed in the human insulin promoter-lymphocytic choriomeningitis mouse model of type 1 diabetes that autoreactive cd8+ t cells depend on cd4+ t-cell–mediated recruitment to the pancreatic islets. |
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