PedAM
Pediatric Disease Annotations & Medicines
| Disease | diabetes mellitus, insulin-dependent |
| Phenotype | C0022658|nephropathy |
| Sentences | 81 |
| PubMedID- 25686570 | Prevention: intensive exercise associated with reduced risk of diabetic nephropathy in patients with type 1 diabetes mellitus. |
| PubMedID- 26239688 | Microalbuminuria provides the earliest clinical marker of diabetic nephropathy among patients with type 1 diabetes, yet it lacks sensitivity and specificity for early histological manifestations of disease. |
| PubMedID- 20667095 | Effects of mcf2l2, adipoq and sox2 genetic polymorphisms on the development of nephropathy in type 1 diabetes mellitus. |
| PubMedID- 21826596 | Effects of panax notoginoside on the nephropathy in rats with type 1 diabetes mellitus. |
| PubMedID- 23909911 | Thus, we sought to evaluate the concordance over time of retinopathy and nephropathy in patients with type 1 diabetes during the diabetes control and complications trial. |
| PubMedID- 21660261 | Showed that the restriction of dietary protein plus phosphate intake was welltolerated and maintained nutritional parameters in a satisfying range in a study of 35 type i diabetes patients with associated nephropathy [15]. |
| PubMedID- 24918158 | Thus, with current treatment of nephropathy in type 1 diabetes, the prognosis and loss of renal function has improved along with better control of modifiable risk factors. |
| PubMedID- 25740786 | An elevated level of growth hormone (gh) is implicated as a causative factor in the development of nephropathy in patients with type 1 diabetes mellitus. |
| PubMedID- 22819809 | Introduction: persistent microalbuminuria is the accepted marker for early detection of a high risk of developing diabetic nephropathy in patients diagnosed with type i diabetes mellitus. |
| PubMedID- 25032099 | Although diabetic nephropathy due to type 1 diabetes mellitus (t1dm) has been studied more extensively, the vast majority of the diabetic ckd patients suffer from type 2 diabetes mellitus (t2dm). |
| PubMedID- 20456170 | Evidence suggests that the increase in cvd risk in type 1 diabetes is largely associated with nephropathy (60–64). |
| PubMedID- 24667182 | Therefore, pemt inhibitors may be useful in the treatment of diabetic nephropathy in patients with type 1 diabetes, as well as for other er stress- and oxidative stress-related diseases. |
| PubMedID- 24688725 | To this end the summit consortium has assembled and phenotyped the largest genome-wide association study (gwas) database for type 1 diabetes patients with diabetic nephropathy (dn). |
| PubMedID- 26339138 | A very recent publication reports a close association between ficolin and diabetic nephropathy in patients with type 1 diabetes [19]. |
| PubMedID- 23858799 | Introduction: the prevalence of microalbuminuria (ma), the most important early marker of incipient nephropathy in patients with type 1 diabetes mellitus (t1dm), increases during puberty, the period of exaggerated physiological insulin resistance. |
| PubMedID- 21876774 | Snps were genotyped using sequenom or taqman technologies in 1351 individuals with type 1 diabetes (651 cases with nephropathy and 700 controls without nephropathy). |
| PubMedID- 25109108 | Association of renin-angiotensin system genes polymorphism with progression of diabetic nephropathy in patients with type 1 diabetes mellitus. |
| PubMedID- 20693588 | Background & objectives: the efficacy of the combination of angiotensin receptor blockers (arbs) and angiotensin converting enzyme (ace) inhibitors in patients of type 1 diabetes mellitus (dm) with nephropathy is debatable. |
| PubMedID- 24527422 | Continuous microalbuminuria (30-299 mg/day) appears in the early stages of diabetic nephropathy with type 1 diabetes, and it is an indicator of nephropathy onset and the development of cardiovascular disease [5]. |
| PubMedID- 26340273 | Since fibroblasts from type 1 diabetes patients (t1dm) with nephropathy exhibit increased proliferation, we studied cell viability, basal ck2 expression and activity, and response to specific ck2 inhibitors tbb (4,5,6,7-tetrabenzotriazole) and cx4945, in fibroblasts from t1dm patients either with (t1dm+) or without (t1dm-) nephropathy, and from healthy controls (n). |
| PubMedID- 24658196 | Haptoglobin genotype and risk of diabetic nephropathy in patients with type 1 diabetes mellitus: a study on a spanish population. |
| PubMedID- 22643932 | It is, however, not known whether such snps also confer susceptibility to diabetic nephropathy in patients with type 1 diabetes mellitus. |
| PubMedID- 19918004 | In particular, several lines of evidence have highlighted the fact that predisposition to hypertension might be a risk factor for the development and progression of diabetic nephropathy in individuals with type 1 diabetes (4–8), and, therefore, the inheritance of blood pressure–related genes might also contribute to abnormal albumin excretion and renal damage. |
| PubMedID- 22923064 | Aims/hypothesis: hba(1c) variability has been shown to be an independent risk factor for nephropathy in patients with type 1 diabetes. |
| PubMedID- 21810600 | It is likely that leptin is beneficial for nephropathy in patients with insulin-dependent diabetes. |
| PubMedID- 21533091 | In contrast to previous studies in which good glucose control prevented, but did not reverse, nephropathy in a model of type 1 diabetes [2], in the present studies the ketogenic diet reversed nephropathy, as reflected by albumin/creatinine ratios, after it had developed in models of both type 1 and type 2 diabetes. |
| PubMedID- 20437026 | The relationship of retinal vessel diameter to changes in diabetic nephropathy structural variables in patients with type 1 diabetes. |
| PubMedID- 20332124 | Conclusions: these findings suggest a role of inflammation and endothelial dysfunction as markers and contributors of the development of diabetic nephropathy in persons with type 1 diabetes mellitus. |
| PubMedID- 24983394 | Early diabetic nephropathy in type 1 diabetes: new insights. |
| PubMedID- 21192815 | To date, it has been shown to be reproducible in healthy volunteers[23,24] and to detect increased wall thickness in selected patients with known coronary artery disease, type 1 diabetes complicated by diabetic nephropathy, and asymptomatic individuals from the mesa study[10,12-14,25]. |
| PubMedID- 20168990 | Significant association was not detected between this snp and nephropathy in those with type 1 diabetes. |
| PubMedID- 23226566 | Moreover, a vdr haplotype between bsmi and taqi was protective against nephropathy in patients with type 1 diabetes, although foki polymorphisms had no significant association with the nephropathy [20]. |
| PubMedID- 20490454 | Ddost, prkcsh and lgals3, which encode age-receptors 1, 2 and 3, respectively, are not associated with diabetic nephropathy in type 1 diabetes. |
| PubMedID- 24781861 | Objective: estimation of glomerular filtration rate (egfr) is one of the current clinical methods for identifying risk for diabetic nephropathy in subjects with type 1 diabetes (t1d). |
| PubMedID- 21355059 | Is treatment of nephropathy in type 1 diabetes efficacious but ineffective. |
| PubMedID- 25634228 | Aims/hypothesis: the aim of this study was to assess how physical activity predicts the development and progression of diabetic nephropathy in patients with type 1 diabetes. |
| PubMedID- 25380925 | The indication for spktx was end-stage diabetic nephropathy due to long-lasting diabetes type 1. |
| PubMedID- 19563389 | Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. |
| PubMedID- 21747824 | Abnormal excretion of protein is a clinically relevant indicator of impending diabetes-related renal damage; however, mechanisms underlying proteinuria in diabetic nephropathy associated with type 1 diabetes mellitus (t1d) are not completely understood. |
| PubMedID- 23346076 | Obviously, the heterozygous index is high compared to the percentage of homozygous and increased from the group of non-diabetic control subjects, to type 1 diabetes (t1d) patients without diabetic nephropathy and the patients with diabetic nephropathy. |
| PubMedID- 23681557 | We hypothesised that variations in the cd2ap gene may contribute to susceptibility to glomerular injury in diabetes and investigated if single-nucleotide polymorphisms (snps) in cd2ap are associated with diabetic nephropathy in patients with type 1 diabetes. |
| PubMedID- 25575985 | Methods: the most recent childbirth of 108 consecutive type 1 diabetes patients with diabetic nephropathy and a singleton pregnancy were studied. |
| PubMedID- 21963083 | We investigated associations of allelic variations in sod1 gene with nephropathy in patients with type 1 diabetes. |
| PubMedID- 23844944 | Associations and interactions between lipid profiles, retinopathy and nephropathy in patients with type 1 diabetes: the finndiane study. |
| PubMedID- 25622104 | The possible benefit of lasp1 as a biomarker is not restricted to cancer, as lasp1 is one out of 12 differentially expressed proteins that show decreased expression in cultured skin fibroblasts of insulin-dependent type 1 diabetes mellitus patients with diabetic nephropathy versus diabetics without nephropathy or healthy subjects. |
| PubMedID- 23543049 | Conclusion: the association of snp loci derived from gwas in european type 1 diabetes with diabetic nephropathy was not replicated in the japanese patients with type 2 diabetes, although the erbb4 locus may have some effect also in japanese type 2 diabetes. |
| PubMedID- 21180245 | Further studies are necessary in order to demonstrate or exclude the role of cat gene in diabetic nephropathy in patients with type 1 diabetes. |
| PubMedID- 24587794 | The aim of the study was to investigate whether a pro12ala polymorphism in the peroxisome proliferator-activated receptor gamma 2 (ppar gamma 2) gene is associated with the progress of diabetic nephropathy in patients with type 1 diabetes. |
| PubMedID- 22518298 | Clinically, inflammatory processes in the kidney also contribute to the progression of nephropathy in patients with type 1 diabetes and in diabetic animal models [14–19]. |
| PubMedID- 20962522 | Conclusion: the a allele of rs1800783 is a significant risk factor for nephropathy in individuals with type 1 diabetes, and further comprehensive studies are warranted to confirm the definitive functional variant in the nos3 gene. |
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