PedAM

Pediatric Disease Annotations & Medicines

Disease	dementia
Phenotype	C0393571\|multiple system atrophy
Sentences	11
PubMedID- 24672633	Alpha-synuclein is strongly implicated in parkinson's disease and other neurodegenerative disorders, such as dementia with lewy bodies, multiple system atrophy, and alzheimer's disease (nucleopathies).
PubMedID- 26096603	However, it is uncertain whether nr4a3 is also involved in diseases such as dementia with lewy bodies, multiple system atrophy, and other neurodegenerative disorders such as tauopathies, tdp-43 proteinopathies and polyglutamine diseases.
PubMedID- 26501269	Atypical parkinsonism syndromes, such as dementia with lewy bodies, multiple system atrophy, progressive supranuclear palsy and corticobasal degeneration, are neurodegenerative diseases with complex clinical and pathological features.
PubMedID- 26452984	In most-but not all-studies published to date total csf alpha-syn concentrations have been found to be decreased in disorders related to alpha-syn pathology, i.e., pd, dementia with lewy-bodies and multiple system atrophy.
PubMedID- 20577640	Lbs are also typical features of other alpha-synucleinopathies such as dementia with lbs and multiple system atrophy.
PubMedID- 21331330	Intracellular, α-syn-positive inclusions are also present in dementia with lbs and multiple system atrophy, which, together with pd, are collectively referred to as synucleinopathies [19].
PubMedID- 22289779	The synucleinopathies discussed in this review are parkinson's disease, dementia with lewy bodies, multiple system atrophy, and neurodegeneration with brain iron accumulation.
PubMedID- 24489820	Aggregates of αs are also found in numerous other neurological disorders such as dementia with lewy bodies, multiple system atrophy, alzheimer’s disease, the parkinsonism-dementia complex of guam, and pantothenate kinase-associated neurodegeneration (formerly known as hallervorden-spatz disease) [19].
PubMedID- 24753321	Based on a comprehensive evidence-based review, the authors propose future avenues of research that ultimately may lead to diagnostic criteria for cognitive impairment and dementia associated with multiple system atrophy.
PubMedID- 22037599	Alpha-synuclein in the cerebrospinal fluid differentiates synucleinopathies (parkinson disease, dementia with lewy bodies, multiple system atrophy) from alzheimer disease.
PubMedID- 24860424	In particular, ps129 asyn is found in lbs occurring and other pathogenic inclusions found in substantia nigra of pd patients (fujiwara et al., 2002; saito et al., 2003; anderson et al., 2006) as well as in different brain regions of patients suffering from other synucleinopathies, such as dementia with lbs (dlb), multiple system atrophy (fujiwara et al., 2002; kahle et al., 2002; saito et al., 2003; nishie et al., 2004; waxman and giasson, 2008), hallervorden-spatz disease (fujiwara et al., 2002), pure autonomic failure (arai et al., 2000b), and lb variant of ad (lbvad) (waxman and giasson, 2008).

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