PedAM
Pediatric Disease Annotations & Medicines
| Disease | dementia |
| Phenotype | C0011847|diabetes |
| Sentences | 68 |
| PubMedID- 24764190 | Second, large-scale and longitudinal studies have shown that diabetes increases the rate of developing dementia (biessels et al., 2006; van harten et al., 2007), implicating hyperglycemia in neurodegeneration. |
| PubMedID- 24622755 | Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements. |
| PubMedID- 20739645 | Cox proportional hazards and multiple logistic regression models were used to analyze the association of diabetes with dementia and neuropathology, respectively. |
| PubMedID- 26381432 | Background: in absence of curative treatments for dementia with type 2 diabetes mellitus (t2dm), mild cognitive impairment (mci) in t2dm, the preclinical transitional states of dementia with t2dm has attracted dramatic attention. |
| PubMedID- 24843645 | Reviewed the risk of dementia in diabetes mellitus, indicating that atherosclerosis such as brain infarction, microvascular disease due to insidious ischemia, advanced protein glycation and oxidative stress due to glucose toxicity, and insufficient insulin action were major factors, and the added involvement of aging and genetic factors leads to dementia1. |
| PubMedID- 26193295 | Furthermore, cognitive decline and dementia were associated with poorer diabetes management. |
| PubMedID- 26061334 | Although the prevalence of dementia was high in patients with diabetes, the causal relationship between diabetes and dementia is still not fully understood. |
| PubMedID- 22110351 | Since ad patients show reduced insulin signaling in the brain and diabetes increases the risk of developing dementia, there are many approaches to increase insulin in the brain. |
| PubMedID- 19683583 | Subjects included 48 non-dementia patients with type 2 diabetes, who were divided into two groups, high vfa group (mean+/-standard deviation: age=65+/-6 years, n=30) and normal vfa group (65+/-5 years, n=18). |
| PubMedID- 20932588 | In multivariate cox proportional hazard models, diabetes increased the risk of either dementia in alzheimer's disease or vascular dementia in men and women, controlling for age, hypertension, total cholesterol, alcohol drinking, and smoking. |
| PubMedID- 23003116 | Hypoglycaemic episodes and risk of dementia in diabetes mellitus: 7-year follow-up study. |
| PubMedID- 21137661 | Based on our finding ,the changes in the neural connection between serotonergic nuclei and hippocampus followed diabetes might be one of the reasons for dementia in these patients. |
| PubMedID- 20891020 | It will be important to ascertain whether risk-factor modification reduces the hr for dementia in persons with diabetes, and to further examine effects of medication use for comorbid conditions. |
| PubMedID- 25252018 | Noninfectious diseases including cardiovascular disease (cvd), cancer and diabetes are major causes of death, whereas dementia cases are also increasing to 'epidemic' proportion. |
| PubMedID- 26173052 | We sought to explore whether ide genes play a role in the association of diabetes with dementia, ad, and structural brain changes using data from two community-based cohorts of older adults and a subsample with structural mri. |
| PubMedID- 21435176 | Conversely, the rotterdam study [3] observed increased risk of dementia in patients with diabetes treated with insulin. |
| PubMedID- 25437406 | Background: type 2 diabetes is associated with dementia risk, but evidence is limited for possible associations of diabetes and prediabetes with cognitive decline. |
| PubMedID- 20229808 | Therefore, insulin sensitizers may have one of the effective measures of the prevention of both types of dementia in people with diabetes mellitus. |
| PubMedID- 25509243 | Treatment of vascular dementia in diabetes patients rests on a two-pronged approach: modification of the underlying disease and prevention and treatment of dementia symptoms. |
| PubMedID- 25946000 | For instance, there is convincing evidence of an increased risk of dementia in people with diabetes, including a strong link between type 2 diabetes and alzheimer's disease [33]. |
| PubMedID- 23605454 | The increased prevalence of cardiovascular risk factors, such as hypertension, dyslipidemia, and hyperglycemia, could lead to increased inflammation, oxidative stress and endothelial dysfunction, and increased prevalence of cerebrovascular disease, which may explain the increased risk of vascular dementia with diabetes [47]. |
| PubMedID- 25941422 | Preliminary results of highly localized plantar irradiation with low incident levels of mid-infrared energy which contributes to the prevention of dementia associated with underlying diabetes mellitus. |
| PubMedID- 25954754 | This also means that membrane transporters, including ion channels and transporters, are very important therapeutic targets in several diseases such as cardiovascular disorders, hypertension, dementia, metabolic syndrome associated with diabetes mellitus, and cancer. |
| PubMedID- 22521970 | Antihypertensive drug use and the risk of dementia in patients with diabetes mellitus. |
| PubMedID- 24339978 | Moreover several studies have reported an increased risk of dementia in subjects with non-insulin-dependent diabetes mellitus [50]. |
| PubMedID- 25673256 | Our objective was to determine whether a similar risk of subsequent dementia is associated with type 1 diabetes in a large defined population. |
| PubMedID- 24843511 | Further examination of the results of large scale, longstanding research, such as the dcct/edic study, is expected to clarify the respective mechanisms and help the prevention of dementia in people with diabetes mellitus. |
| PubMedID- 20713684 | Therefore, an additional increased risk of developing dementia resulting from diabetes can be expected in people with mci. |
| PubMedID- 22403298 | However, accumulating evidence suggests that small-vessel disease also is important for neurologic disorders such as dementia and stroke in patients with diabetes (25–27). |
| PubMedID- 23840309 | Since cognitive decline as well as increased dementia are strongly associated with diabetes and previous studies addressed the protective effect of bdnf in metabolic syndrome and type 2 diabetes; hence this work aimed to evaluate the potential neuroprotective effect of cbl in modulating the complications of hyperglycaemia experimentally induced by streptozotocin (stz) on the rat brain hippocampus. |
| PubMedID- 22654720 | Alzheimer’s is the most common form of dementia and, with diabetes, it is the 7th leading cause of death in the u.s. between 2000 and 2006, deaths because of ad increased by over 46%. |
| PubMedID- 25852732 | Studies have repeatedly demonstrated that type 2 diabetes increases the risk of cognitive impairment and dementia, including ad [7,8,9,10,11,12,13,14,15]. |
| PubMedID- 24623199 | Furthermore, novel therapeutic strategies will be needed to prevent or reduce the development of dementia in people with diabetes mellitus. |
| PubMedID- 20044657 | Risk of developing dementia in people with diabetes and mild cognitive impairment. |
| PubMedID- 22701197 | To evaluate the association of apolipoprotein e4 (apoe4) in alzheimer's dementia (ad) with comorbid diabetes mellitus (dm). |
| PubMedID- 21778636 | In cases of dementia in elderly with diabetes, a catheter from a femoral vein is frequently used to prevent complications. |
| PubMedID- 24843720 | These are important determinants of the increased risk of dementia in people with diabetes, and likely to help in understanding the factors that are associated in diabetes patients, which can then be better regulated. |
| PubMedID- 23596182 | It was shown that insulin signaling was altered in the brain in alzheimer disease (14), which is the most common cause of dementia in people with type 2 diabetes (15). |
| PubMedID- 21337033 | Finally, prevalence of uncontrolled hypertension and diabetes, known causes of dementia, is higher in african americans [17, 40–42]. |
| PubMedID- 23428182 | The breakdown of the blood-brain barrier (bbb) is associated with dementia in patients with type 2 diabetes mellitus (t2dm). |
| PubMedID- 20829391 | Impairment of insulin and igf-i signaling in the brain is one of the causes of dementia associated with diabetes mellitus and alzheimer's disease. |
| PubMedID- 25984790 | Moderate to severe liver disease, any tumor (including leukemia and lymphoma), diabetes with end-organ damage, dementia, and cerebrovascular disease followed consecutively. |
| PubMedID- 25926349 | A growing body of evidence links type-2 diabetes (t2d) with dementia and neurodegenerative diseases such as alzheimer's disease (ad). |
| PubMedID- 23299282 | Risk factors for dementia with type 2 diabetes mellitus among elderly people in china. |
| PubMedID- 26457080 | The authors suggested that such studies might elucidate possible epigenetic mechanisms explaining the increased risk of dementia among persons with diabetes; however, one might argue that it could shed light on possible epigenetic mechanisms explaining the increased prevalence and incidence of depression among persons with diabetes as well. |
| PubMedID- 22147809 | Association of depression with increased risk of dementia in patients with type 2 diabetes: the diabetes and aging study. |
| PubMedID- 26233574 | Association between comorbidities and dementia in diabetes mellitus patients: population-based retrospective cohort study. |
| PubMedID- 20299484 | Previous studies on cognitive functioning or dementia in patients with diabetes did not observe sex-specific increases in the rate of cognitive decrements (2). |
| PubMedID- 21948010 | Aim: to determine the risk of developing dementia in subjects with type 2 diabetes mellitus. |
| PubMedID- 23217243 | Additional objectives included: (i) exploring the associations between lp-pla2 and cerebrospinal fluid (csf) markers of ad, (ii) assessing the association of lp-pla2 and markers of cardiovascular disease or diabetes in individuals with dementia, and (iii) investigating the relationship between lp-pla2 and apoe genotype. |
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