PedAM
Pediatric Disease Annotations & Medicines
| Disease | crohn disease |
| Phenotype | C0011854|type 1 diabetes |
| Sentences | 1 |
| PubMedID- 26110739 | Most notably, the ratio of low to high impact missense varies from about 2 for coronary artery disease and type 2 diabetes, to 0.5 for crohn's disease, with bipolar disorder, type 1 diabetes and rheumatoid arthritis having intermediate ratios of about 1. a possible explanation for these striking differences is related to the fact that the diseases with a high proportion of low impact snps (type 2 diabetes and coronary artery disease) are late onset, while those with lower values (crohn's disease, bipolar disorder, type 1 diabetes) are early onset. |
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