PedAM
Pediatric Disease Annotations & Medicines
| Disease | constipation |
| Phenotype | C0007102|colon cancer |
| Sentences | 1 |
| PubMedID- 20551579 | It has been hypothesized that constipation increases colon cancer risk because it results in longer transit times in the colon, which increases the duration of contact between the colonic mucosa and concentrated carcinogens in the lumen.40,41 possible carcinogenic agents within stool include bile acids,42,43 fecapentaene,44 and ammonium acetate.45 constipation is also a major symptom of colorectal cancer; however, in this study the authors informed participants that they should focus on bowel habits that began in adolescence through working age until 1 year before illness, and reminded them to think of any changes in bowel habits, to avoid information bias. |
Page: 1