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PedAM

Pediatric Disease Annotations & Medicines




Disease common variable immunodeficiency
Phenotype C0021831|bowel disease
Sentences 3
PubMedID- 24952714 common variable immune deficiency can present with inflammatory bowel disease-like colitis because of the dysregulated immune system; paradoxically activated t cell receptor pathways are thought to be pivotal in pathogenesis of common variable immune deficiency-related colitis.
PubMedID- 25716035 Inflammatory bowel disease-like colitis pathology in a patient with common variable immune deficiency.
PubMedID- 24499503 In the first case, a 34-year-old male with cvid complicated by inflammatory bowel disease, hepatic hyperplasia, splenomegaly, and portal hypertension, obtained a partial response for at least 11 months, and the authors were the first to suggest that treatment with rituximab might be an option for patients with cvid and itp refractory to other treatments (or for those in whom splenectomy is contraindicated) [39].

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