PedAM
Pediatric Disease Annotations & Medicines
| Disease | colorectal neoplasms |
| Phenotype | C0032580|familial adenomatous polyposis |
| Sentences | 2 |
| PubMedID- 21386833 | The exclusion criteria were:family or personal history of colorectal neoplasia including familial adenomatous polyposis or hereditary nonpolyposis crc.previous colonoscopy, within preceding 10 years.diagnosis of suspected inflammatory bowel disease, bowel obstruction, or acute diverticulitis, or known severe diverticulosis, or any known large-bowel disease.clinically significant cardiovascular or pulmonary disease.gastrointestinal tract-related symptoms, complaints, or diseases suggesting performance of a diagnostic colonoscopy (nonscreening cases).cancer or other life-threatening disease or significant chronic condition.blood-clotting disorders and/or anticoagulant therapy (anticoagulant therapy included aspirin within the previous 7 days).known pregnancy or positive pregnancy-screening test.previous abdominal surgery, except for uncomplicated cholecystectomy, appendectomy, or minor pelvic surgery (e.g., hernia repair, oöphorectomy).morbid obesity (body mass index >40 kg/m2).clinically significant abnormal screening laboratory findings.clinically significant abnormal screening electrocardiographic findings.drug abuse or alcoholism.inability of the screenee to communicate adequately.being under custodial care.participation in a clinical study within the previous 30 days. |
| PubMedID- 24383454 | Immunohistochemical studies generally showed more staining in the tumor as compared to the normal colorectal mucosa, however staining positivity in the tumor varied from 35 to 62% in sporadic colorectal cancers [12,14] to 100% staining positivity in colorectal tumors from patients with familial adenomatous polyposis [13]. |
Page: 1