PedAM
Pediatric Disease Annotations & Medicines
| Disease | colorectal cancer |
| Phenotype | C1333990|lynch syndrome |
| Sentences | 51 |
| PubMedID- 20010342 | Prevention of metachronous colorectal cancer in patients with lynch syndrome. |
| PubMedID- 26064726 | Microsatellite instability (msi) is a hypermutable phenotype caused by the loss of dna mismatch repair activity, and it is detected in about 15% of all colorectal cancers; 3% are associated with lynch syndrome and the other 12% occur sporadically [1]. |
| PubMedID- 20495877 | Magnetic resonance colonography for colorectal cancer screening in patients with lynch syndrome gene mutation. |
| PubMedID- PMC3288925 | Msi is present in 80-85% of colorectal cancers associated with lynch syndrome. |
| PubMedID- 25213040 | Aim: colonic surveillance reduces the lifetime risk of colorectal cancer in patients with lynch syndrome (hereditary nonpolyposis colorectal cancer) from 60 to 80% to 10% and confers a 7-year survival advantage. |
| PubMedID- 23245329 | Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with fcctx from lynch syndrome, which likely signifies different preferred tumourigenic pathways. |
| PubMedID- 22175017 | However, there have been fewer studies on endometrial cancer compared to colorectal cancer in patients with lynch syndrome. |
| PubMedID- 22940821 | Thus, in patients with lynch syndrome the risk of developing colorectal cancer throughout life is approximately 80% and 40–60% in males and females, respectively, while that of developing endometrial cancer throughout life is 40–60%. |
| PubMedID- 21743847 | The american college of gastroenterology found moderate quality evidence for their recommendation that colorectal cancer patients with lynch syndrome undergo colonoscopy every 2 years beginning at age 20-25 and then annually after age 40 [9]. |
| PubMedID- 23470269 | Background: colorectal cancer (crc) associated with lynch syndrome usually presents at a relatively young age. |
| PubMedID- 23484096 | Affected individuals have approximately 60–80% lifetime risk of developing colorectal cancer and women with lynch syndrome have 54% risk of developing endometrial cancer [2]. |
| PubMedID- 26284327 | The lifetime risk of colorectal cancer for males with lynch syndrome generally is significantly higher and the age of first manifestation significantly earlier compared to females. |
| PubMedID- 23657759 | lynch syndrome (ls) is one of the inherited colorectal cancer (crc) syndromes and is due to germline mutations in one of the mismatch repair (mmr) genes. |
| PubMedID- 23392144 | Increasing lynch syndrome identification through establishment of a hereditary colorectal cancer registry. |
| PubMedID- 25816162 | However, a higher frequency of mmr-dcf was observed in lynch syndrome patients with distal colorectal cancer localisation. |
| PubMedID- 23073955 | lynch syndrome in patients with colorectal cancer: finding the needle in the haystack. |
| PubMedID- 22411104 | Daily aspirin reduces colorectal cancer incidence in patients with lynch syndrome. |
| PubMedID- 22480969 | Background: recommended strategies to screen for lynch syndrome in colorectal cancer are not applied in daily practice and most of lynch cases remain undiagnosed. |
| PubMedID- 25583420 | Relationship between smoking and multiple colorectal cancers in patients with japanese lynch syndrome: a cross-sectional study conducted by the japanese society for cancer of the colon and rectum. |
| PubMedID- PMC2876284 | This study analyzes precursor polyp burdens occurring within patients with msi-h colorectal cancers associated with lynch syndrome (ls) or those with a methylator pathway cancer phenotype. |
| PubMedID- 21159521 | Perspectives for tailored chemoprevention and treatment of colorectal cancer in lynch syndrome. |
| PubMedID- 23951239 | The national danish hnpcc register was used to identify colorectal cancers from individuals with lynch syndrome and fcctx. |
| PubMedID- 23073952 | Identification of lynch syndrome among patients with colorectal cancer. |
| PubMedID- 23896635 | Although variable, the lifetime risk of developing colorectal cancer (crc) in patients with lynch syndrome is approximately 80 %, with male carriers having a higher cumulative risk than female carriers [2]. |
| PubMedID- 22262812 | colorectal cancers associated with lynch syndrome are characterized by deficient dna mismatch repair (mmr) function. |
| PubMedID- 26249337 | Three patients were diagnosed with lynch syndrome, comprising 2.2 % of the total colorectal cancer patients younger than 60 years of age. |
| PubMedID- 25731324 | [effect of chemotherapy on the inoperable or recurrent colorectal cancers in patients with lynch syndrome]. |
| PubMedID- 25323653 | Applying public health screening criteria: how does universal newborn screening compare to universal tumor screening for lynch syndrome in adults with colorectal cancer. |
| PubMedID- 20206180 | One to 2-year surveillance intervals reduce risk of colorectal cancer in families with lynch syndrome. |
| PubMedID- 23508345 | The surgical management of the lynch syndrome patient with colorectal cancer needs to be individualized. |
| PubMedID- 22056658 | Interpretation of genetic testing for lynch syndrome in patients with putative familial colorectal cancer. |
| PubMedID- 25142628 | The percentage of cancers revealed in 1st (2%) and 2nd degree (8%) relatives were increasing through surveys, especially colorectal cancer related with lynch syndrome (4%). |
| PubMedID- 21233718 | Purpose: lynch syndrome accounts for 2-4% of all colorectal cancer, and is mainly caused by germline mutations in the dna mismatch repair genes. |
| PubMedID- 23125224 | Cell cycle-related genes as modifiers of age of onset of colorectal cancer in lynch syndrome: a large-scale study in non-hispanic white patients. |
| PubMedID- 25534380 | Short-term risk of colorectal cancer in individuals with lynch syndrome: a meta-analysis. |
| PubMedID- 25910169 | The objective of this project was to estimate the cost-utility of strategies to identify lynch syndrome in individuals with early-onset colorectal cancer in the nhs. |
| PubMedID- 24533633 | colorectal cancer in lynch syndrome have distinctive clinical features that are well known in literature, such as younger age at presentation, proximal location, mucinous differentiation, advanced stage, associated extracolonic tumors and better stage-normalized prognosis [2,6,17]. |
| PubMedID- 24225971 | Molecular tumor testing for lynch syndrome in patients with colorectal cancer. |
| PubMedID- 26473097 | Testing for lynch syndrome in patients with newly-diagnosed colorectal cancer and their relatives. |
| PubMedID- 25081898 | Background: recognising colorectal cancer (crc) patients with lynch syndrome (ls) can increase life expectancy of these patients and their close relatives. |
| PubMedID- 23598716 | Purpose: routine screening for evidence of dna mismatch repair abnormalities can identify colorectal cancer patients with lynch syndrome, but impact in usual care settings requires study. |
| PubMedID- 22237445 | Implementing screening for lynch syndrome among patients with newly diagnosed colorectal cancer: summary of a public health/clinical collaborative meeting. |
| PubMedID- 20303416 | We reviewed an integrated electronic health record (ehr) to determine diagnostic evaluation for lynch syndrome in patients diagnosed with colorectal cancer (crc). |
| PubMedID- 24759670 | Some colorectal cancers with lynch syndrome-like pedigrees remain mutation-negative in a dna mismatch repair (mmr) gene analysis [14]. |
| PubMedID- 22359099 | Up to 5% of all colorectal cancer cases are attributed to the lynch syndrome [1].lynch syndrome is caused by germ line mutations in one of the mismatch repair (mmr) genes mlh1, msh2, msh6 or pms2 [2]. |
| PubMedID- 21768580 | Strategies to identify the lynch syndrome among patients with colorectal cancer: a cost-effectiveness analysis. |
| PubMedID- 25794514 | Approximately 3% of colorectal cancers are associated with lynch syndrome. |
| PubMedID- 23733757 | Purpose: molecular screening techniques are available to identify hereditary lynch syndrome in people with newly diagnosed colorectal cancer (crc). |
| PubMedID- 19957108 | Serum antibodies against frameshift peptides in microsatellite unstable colorectal cancer patients with lynch syndrome. |
| PubMedID- 24056992 | Some studies reported since publication of the egapp analysis have added to the evidence regarding clinical utility to the relatives of colorectal cancer patients diagnosed with lynch syndrome. |
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