PedAM
Pediatric Disease Annotations & Medicines
| Disease | colorectal cancer |
| Phenotype | C0009319|colitis |
| Sentences | 35 |
| PubMedID- 24766737 | In a metaanalysis based on 116 studies, the overall prevalence of colorectal cancer in patients with ulcerative colitis was 3.7%. |
| PubMedID- 25823771 | It has been more than 40 years since the colonoscopic surveillance program for colorectal cancer (crc) in patients with long-standing ulcerative colitis (uc) was introduced (1). |
| PubMedID- 21404516 | colorectal cancer, in patients with ulcerative colitis, is detected in the resected tissue of approximately 5% of patients, according to the literature. |
| PubMedID- 21468069 | Whether or not 5-aminosalicylates can prevent colorectal cancer among patients with colitis remains an open question. |
| PubMedID- 23867875 | Methylated eyes absent 4 (eya4) gene promotor in non-neoplastic mucosa of ulcerative colitis patients with colorectal cancer: evidence for a field effect. |
| PubMedID- 25649787 | Despite a low overall risk of colorectal cancer in patients with ulcerative colitis of relatively short duration, there is evidence that malignancies may be missed in that initial window. |
| PubMedID- 26357617 | Risk factors for developing cca in psc patients include elevated serum bilirubin, chronic ulcerative colitis with colorectal cancer or dysplasia, variceal bleeding, proctocolectomy, and polymorphisms of the natural killer group 2, member d (nkg2d) gene (encoding a protein involved in nk cell activity).78, 82, 83 the duration of psc may not be a risk factor for the development of cca, which is contrary to the risk factors of neoplasia in inflammatory bowel disease.77 it is suggested that dominant strictures, defined as a common bile duct stenosis with less than 1.5 mm diameter remaining in the common bile duct or a common hepatic duct stenosis close to the bifurcation leaving less than 1.0 mm diameter of the common hepatic duct,84, 85 may serve as primary indicators of concomitant cca.86 it is very challenging to distinguish between benign strictures from psc activity and cca as they can have similar characteristics on imaging. |
| PubMedID- 25029614 | colorectal cancer associated with chronic colitis arises from dysplasia. |
| PubMedID- 25078150 | Patients with colitides have increased reactive oxidative stress (ros), dna oxidation products, free iron in mucosa, in preneoplastic, and in colitis-cancers and increased risks of developing colorectal cancer. |
| PubMedID- 25412264 | Nuclear factor-kappa b (nf-kappab) is an important molecule in mediating inflammatory colitis, which can lead to colorectal cancer (crc). |
| PubMedID- 23435402 | Five-year mortality in colorectal cancer patients with ulcerative colitis or crohn's disease: a nationwide population-based cohort study. |
| PubMedID- 25437823 | The incidence of dysplasia and colorectal cancer in patients with long-standing colitis seems to be decreasing and controversy surrounds our detection and management strategies. |
| PubMedID- 21425209 | Myeloperoxidase immunohistochemistry as a measure of disease activity in ulcerative colitis: association with ulcerative colitis-colorectal cancer, tumor necrosis factor polymorphism and runx3 methylation. |
| PubMedID- 22552273 | Dysplasia and colorectal cancer in a patient with ulcerative colitis and primary sclerosing cholangitis: a case report and a short review of the literature. |
| PubMedID- 23446340 | The risk of colorectal cancer in patients with long-standing ulcerative colitis or colonic crohn's disease is increased. |
| PubMedID- 21618350 | Background: chronic ulcerative colitis (uc) is associated with an increased colorectal cancer risk which may be secondary to repetitive mucosal injury. |
| PubMedID- 21979184 | Increased risk of colorectal cancer and dysplasia in patients with crohn's colitis and primary sclerosing cholangitis. |
| PubMedID- 21793125 | Background: ulcerative colitis (uc) is associated with colorectal cancer. |
| PubMedID- 25981516 | Psc is a premalignant condition, associated with higher rates of hepatobiliary and colorectal cancer in patients with ulcerative colitis (uc). |
| PubMedID- 20157368 | In patients with inflammatory bowel disease such as ulcerative colitis, the risk of colorectal cancer begins to increase after 8 to 10 years and increases approximately 1% per year thereafter, particularly in patients with pancolitis [15]. |
| PubMedID- 25888857 | Avoiding restorative proctocolectomy for colorectal cancer in patients with ulcerative colitis based on preoperative diagnosis involving p53 immunostaining: report of a case. |
| PubMedID- 21859497 | Importantly, it has been reported that the administration of 0.6% curcumin in the diet prevented the progression of colorectal cancer associated with colitis in c57bl/6 mice by inhibiting the translocation of β-catenin from adherens junction complexes to the cytoplasm and nucleus and reducing the levels of diverse proinflammatory cytokines, inducible nitric oxide synthase (inos) and cox-2 as compared to untreated mice (figure 1) [167]. |
| PubMedID- 21722342 | Sulfasalazine has even been postulated as chemo-prevention of colorectal cancer in patients with colitis ulcerosa [8]. |
| PubMedID- 25003294 | Dysplasia in ulcerative colitis as a predictor of unsuspected synchronous colorectal cancer. |
| PubMedID- 23118901 | Inflammation plays a crucial role in the cancer development [4], and chronic inflammation leading to inflammatory bowel disease (crohn's disease and ulcerative colitis) is associated with colorectal cancer risk [5]. |
| PubMedID- 25834332 | Aim: to determine the incidence and risk factors for colorectal cancer (crc) in patients with ulcerative colitis from a low prevalence region for crc. |
| PubMedID- 20656250 | The incidence of colorectal cancer associated with ulcerative colitis (uc) increases with time. |
| PubMedID- 24409181 | Accordingly, mice deficient in caspase-1, asc, nlrp3, nlrp6, nlrp12, and nlrc4 all have increased colitis and subsequent development of colorectal cancers in gut irritant models. |
| PubMedID- 25797989 | Surveillance colonoscopy (sc) is considered important for the early detection and treatment of colorectal cancer (crc) in patients with ulcerative colitis (uc). |
| PubMedID- 24906974 | Sporadic, colitis-associated and inherited forms of colorectal cancer (crc) arise from somatic mutations and/or epigenetic alterations in tumour suppressors and proto-oncogenes.12 the origin of mutations and epigenetic changes that lead to these cancers, however, remains ill-defined. |
| PubMedID- 22312529 | [17] reported good clinical results with laparoscopic isr combined with transanal manipulation prior to the abdominal phase for two patients with t2 very low rectal cancer and total colectomy for two patients with ulcerative colitis complicated by t1 colorectal cancer; feasibility for t3 low rectal cancer could not be evaluated due to the small number of patients. |
| PubMedID- 23295694 | An average of 1.6% of patients with ulcerative colitis was diagnosed with colorectal cancer during 14 years of follow-up in population-based cohorts. |
| PubMedID- 24496155 | Although only 1% of all cases of colorectal cancer (crc) occur in patients with ulcerative colitis (uc) or crohn's disease (cd), patients with ibd represent one of the highest risk groups for developing this dreaded complication. |
| PubMedID- 24829673 | Patients with uc, referred for colonoscopy to shariati hospital, tehran, iran were consecutively recruited between may 2010 and may 2011. exclusion criteria were: crohn’s disease, pregnancy, infectious colitis, history of colorectal cancer, alcohol consumption, and treatment with nsaids, antibiotic and cytotoxic medications. |
| PubMedID- 26079427 | Combined p38γ and p38δ (p38γ/δ) deletion severely reduces chemical azoxymethane (aom)/dss-induced colon tumour formation in a colitis-associated model of colorectal cancer (cac) [16]. |
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