PedAM
Pediatric Disease Annotations & Medicines
| Disease | cleft lip |
| Phenotype | C0008925|cleft palate |
| Sentences | 332 |
| PubMedID- 23044548 | 'location, location, location': a spatial approach for rare variant analysis and an application to a study on non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 25663376 | Genome-wide association studies (gwas) for nonsyndromic cleft lip with or without cleft palate (cl/p) have identified multiple genes as important in the etiology of this common birth defect. |
| PubMedID- 26511190 | E-cadherin coding gene (cdh1) and nonsyndromic cleft lip with or without cleft palate: is there any association. |
| PubMedID- 20662904 | Nonsyndromic cleft lip with or without cleft palate (ncl/p) is one of the most common craniofacial malformations; however, its aetiology is still unclear. |
| PubMedID- 23735067 | Ten patients of >/= 8 years to cleft palate, with or without cleft lip, with no other systemic illness and normal intelligent quotient level, were selected and managed by palatal lift prosthesis. |
| PubMedID- 25918826 | The aetiology of nonsyndromic cleft lip with or without cleft palate (nsclp) is complex and involves both genetic and environmental risk factors. |
| PubMedID- 20963351 | It was found that among the 5 patients, 2 had incomplete right cleft lip with incomplete cleft palate, 2 were affected by left incomplete cleft lip and incomplete cleft palate, and 1 had a cleft lip and palate associated with complete right cleft palate. |
| PubMedID- 25853057 | All participants were recruited between 2009 and 2011, and all patients were screened for the presence of associated anomalies or syndromes by expert geneticists, and only those determined to have isolated cleft lip with or without cleft palate were included. |
| PubMedID- 20634891 | Schweder-spjøtvoll plot of p-values for (a) isolated cleft lip with or without cleft palate (icl/p) and (b) isolated cleft palate (icp). |
| PubMedID- 26436110 | All affected individuals had cleft lip with cleft palate and the laterality information where known is indicated on pedigree. |
| PubMedID- 21781439 | No association between polymorphisms in cubilin, a gene of the homocysteine metabolism and the risk of non-syndromic cleft lip with or without cleft palate. |
| PubMedID- 24942095 | Rfc1 and non-syndromic cleft lip with or without cleft palate: an association based study in italy. |
| PubMedID- 20099315 | The dataset included 5821 controls, 1567 cases of cleft lip with or without cleft palate (cl+/-p) and 835 cases of cleft palate only. |
| PubMedID- 21981552 | Objective: recent genome-wide association studies identified susceptibility loci for nonsyndromic cleft lip with or without cleft palate (nscl+/-p) on 8q24.21, 10q25.3, 13q31.1, 15q13.3, 17q22, and 18q22 in populations of european origin. |
| PubMedID- 26322296 | cleft lip with or without cleft palate of the fetus can also be screened by using ultrasonography. |
| PubMedID- 21462296 | Background: nonsyndromic cleft lip with or without cleft palate (cl/p) is a common complex birth defect caused by the interaction between multiple genes and environmental factors. |
| PubMedID- 20564431 | Genetic risk factors for nonsyndromic cleft lip with or without cleft palate in a mesoamerican population: evidence for irf6 and variants at 8q24 and 10q25. |
| PubMedID- 23512105 | A collection of 1,108 case-parent trios ascertained through an isolated, nonsyndromic cleft lip with or without cleft palate (cl/p) was used to replicate the findings from a genome-wide association study (gwas) conducted by beaty et al. |
| PubMedID- 23326687 | Van der woude syndrome is characterized by pits and sinuses of lower lip, cleft lip with or without cleft palate. |
| PubMedID- 24361572 | In this article, we considered the dihydrofolate reductase (dhfr) gene, previously seen implicated in ntds, as a candidate for cleft lip with or without cleft palate (cl/p) risk. |
| PubMedID- 24278672 | Additional features include: cleft lip with or without cleft palate, congenital heart disease, and congenital renal malformations. |
| PubMedID- 24804503 | [analysis between transforming growth factor beta3 gene sfani polymorphism variant and non-syndromic cleft lip with or without cleft palate in people of uygur's nationality and han's in xinjiang]. |
| PubMedID- 23611445 | When applying structural equation modeling, the effect of multigravidity on the risk of cleft lip with or without cleft palate was 1.22 and the 95% confidence interval was 0.91 to 1.39. |
| PubMedID- 20301704 | Other less common abnormalities include cleft palate with or without cleft lip and unilateral or bilateral choanal stenosis or atresia. |
| PubMedID- 24972815 | Mafb (v-maf musculoaponeurotic fibrosarcoma oncogene homolog b) is a new gene that may be involved in susceptibility to cleft lip with or without cleft palate (cl/p). |
| PubMedID- 21926056 | No association was observed for maternal bronchodilator use and the risk of cleft lip with cleft palate (aor = 0.78, 95% ci: 0.46-1.31). |
| PubMedID- 22374000 | Updating the epidemiology of cleft lip with or without cleft palate. |
| PubMedID- 21969361 | The ors for cleft lip with or without cleft palate and cleft palate and dqi were also notable (0.66 [95% ci, 0.54-0.81] and 0.74 [95%ci, 0.56-0.96], respectively). |
| PubMedID- 20170386 | Conclusions: allelic and haplotypic associations implicate a possible role of tgfb3 in nonsyndromic cleft lip with or without cleft palate in the chilean population. |
| PubMedID- 20572868 | Non-syndromic cleft lip with or without cleft palate (nscl/p) is one of the most common birth defects and has a multifactorial etiology that includes both genetic and environmental factors. |
| PubMedID- 22072571 | Background: nonsyndromic cleft lip with or without cleft palate (ncl/p) is a common structural malformation with a complex and multifactorial etiology. |
| PubMedID- 25007034 | The birth prevalence of cleft lip with or without cleft palate was significantly higher in boys, with a stable boy to girl ratio of 1.75:1. |
| PubMedID- 24134478 | The total birth prevalence was 16.0 per 10,000 births for all orofacial clefts, 8.2 for cleft lip with or without cleft palate, and 7.8 for cleft palate. |
| PubMedID- 21297019 | This study investigated the association between the ofc1 genomic region and non-syndromic cleft lip with or without cleft palate in 90 malay father-mother-offspring trios. |
| PubMedID- 22074045 | The fgf and fgfr gene family and risk of cleft lip with or without cleft palate. |
| PubMedID- 25081408 | Genome-wide association studies (gwas) for nonsyndromic cleft lip with or without cleft palate (nscl[p]) revealed significant association for common single nucleotide polymorphisms near genes involved in craniofacial development i.e., mafb, pax7, vax1, arhgap29 (abca4 locus), and irf6. |
| PubMedID- 23029012 | Of these, 400 had cleft lip with cleft palate (168 with left cleft lip, 154 with bilateral cleft lip, 76 with right cleft lip, and 2 median clefts), six had cleft lip only (two on the right side and four on the left side), 66 had cleft palate only and 28 had unknown cleft types. |
| PubMedID- 23900075 | Defects such as cleft lip with or without cleft palate (cl/p) are among the most common craniofacial birth defects in humans. |
| PubMedID- PMC3237372 | Ecleft lip with or without cleft palate. |
| PubMedID- 21689018 | No significant association was found between nsoc and rs3821949 or rs12532 in msx1 gene, whereas an association was observed between the p147q variant and cleft lip with cleft palate in the case-control analysis. |
| PubMedID- 21303264 | Methods: retrospective chart review of cleft lip with or without cleft palate (cl/p) and cleft palate (cp) cases registered with the cleft and craniofacial team at children's hospital of new orleans, the surgical center that treated cleft cases in greater new orleans between 2004 and 2007. |
| PubMedID- 21885341 | Four gwas of nonsyndromic cleft lip with or without cleft palate have been conducted, and these have identified five new chromosomal loci. |
| PubMedID- 21638763 | Genetic contribution for non-syndromic cleft lip with or without cleft palate (ns cl/p) in different regions of brazil and implications for association studies. |
| PubMedID- 23580168 | The purpose of this study was to investigate the contribution of msx1 gene to the risk of nonsyndromic cleft lip with or without cleft palate (ns-cl +/- p) in the korean population. |
| PubMedID- 24437588 | Introduction: nonsyndromic cleft lip with or without cleft palate (nsclp) is a common birth defect with substantial clinical and social impact. |
| PubMedID- 22511506 | Background: nonsyndromic cleft lip with or without cleft palate is a relatively common craniofacial defect with multifactorial inheritance. |
| PubMedID- 20506229 | Expression and association data strongly support jarid2 involvement in nonsyndromic cleft lip with or without cleft palate. |
| PubMedID- 20809987 | The two main types of orofacial clefts are cleft lip with or without cleft palate (cl/p) and cleft palate (cp) alone. |
| PubMedID- 22976623 | The purpose of this study was to investigate the contribution of pax9 gene to the risk of nonsyndromic cleft lip with or without cleft palate (ns-cl/p). |
| PubMedID- 26361024 | The most common cranial defect was medial cleft lip with cleft palate (27.3%), bilateral cleft lip (11%) or both (38.2%), cyclopia (14%), single nostril (10.9%) and proboscis (9.1%). |