PedAM
Pediatric Disease Annotations & Medicines
| Disease | cholestasis |
| Phenotype | C0023895|liver diseases |
| Sentences | 2 |
| PubMedID- 26366057 | Among the three aspects, cholestasis associated with liver diseases is most commonly featured by the enhancement of reactive oxygen species (ros) and reduction of antioxidant systems such as glutathione (gsh), which finally results in oxidative stress and directly induces the apoptosis of hepatocytes. |
| PubMedID- 23755201 | cholestasis is associated with many liver diseases, and bile duct ligation (bdl) has been used in an animal model of chronic liver injury because it duplicates the hepatocyte damage, hsc activation, and liver fibrosis observed in human liver diseases. |
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