PedAM

Pediatric Disease Annotations & Medicines

Disease	cholestasis
Phenotype	C0023890\|cirrhosis
Sentences	13
PubMedID- 23487357	Explorative laparotomy showed a liver cirrhosis with distinct intrahepatic cholestasis, a hydropic gallbladder and confirmed a right-sided diaphragmatic defect with an enterothorax.
PubMedID- 26233910	Chronic cholestasis is associated with fibrosis, cirrhosis, and eventually liver failure.
PubMedID- 21813017	However, there is no data for the development of secondary biliary cirrhosis (sbc) due to extrahepatic cholestasis in a patient with sit.
PubMedID- 21301964	Histology revealed cirrhosis with marked cholestasis, grade 1 siderosis, and the presence of brown pigment deposits in bile ducts, kupffer cells and hepatocytes with red birefringence consistent with epp.
PubMedID- 25658057	Biliary atresia is a rare disease of unclear etiology, in which obstruction of the biliary tree causes severe cholestasis leading to cirrhosis and ultimately death if left untreated.
PubMedID- 22212619	Chronic cholestasis eventually leads to hepatic cirrhosis and fibrosis, and rodent chronic cholestasis models are used to study aspects of fibrosis and cirrhosis.
PubMedID- 26136783	An ultrasound guided hepatic biopsy revealed cirrhosis and a diagnosis of progressive familial intrahepatic cholestasis (pfic).
PubMedID- 25688837	Our findings suggest that bile canalicular lumen expansion might explain the presence of cholestasis in patients with primary biliary cirrhosis and primary sclerosing cholangitis.
PubMedID- 24147052	Naic is distinguished from established ribosomopathies in that it has a single and unique clinical manifestation (cholestasis leading to biliary cirrhosis).
PubMedID- 23304557	Biliary atresia is a rare neonatal disease of unknown etiology, where obstruction of the biliary tree causes severe cholestasis, leading to biliary cirrhosis and death in the first years of life, if the condition is left untreated.
PubMedID- 24318962	Finally, secondary biliary cirrhosis owing to cholestasis caused by a stricture of the hepaticojejunostomy is the most frequent indication of lt for bdi after cholecystectomy29.
PubMedID- 22232650	Liver fibrosis results from the fibrogenic activation of fibrocytes and hepatic stellate cells, called ito cells, following continuous hepatocytic injury and cholestasis, sometimes leading to liver cirrhosis and hepatocellular carconoma [2,17-19].
PubMedID- 24800007	The spectra of liver manifestations of a1atd are prolonged infantile cholestasis leading to juvenile cirrhosis and slowly progressive adult liver disease[2].

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