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PedAM

Pediatric Disease Annotations & Medicines




Disease cardiomyopathy
Phenotype C0020456|hyperglycemia
Sentences 5
PubMedID- 20828387 Both hyperglycemia and hhcy lead to diabetic cardiomyopathy, which is a leading cause of morbidity and mortality [5-9].
PubMedID- 24324515 The link between hyperglycemia and the development of diabetic cardiomyopathy involves the accumulation of advanced glycation end products (ages) in cardiac tissue.
PubMedID- 22375142 Previous studies from our group support an important role for mbl and the lectin complement pathway in mediating the cardiomyopathy and vasculopathy associated with acute hyperglycemia (busche et al., 2008; pavlov et al., 2012).
PubMedID- 22079428 We hypothesized that cardiomyopathy and vasculopathy resulting from acute hyperglycemia are dependent on mannose-binding lectin (mbl) and lectin complement pathway activation.
PubMedID- 22719862 In diabetic patients, the development of cardiomyopathy is attributable to hyperglycemia and increased modification of proteins with o-glcnac [8]–[11].

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