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PedAM

Pediatric Disease Annotations & Medicines




Disease cardiomyopathy
Phenotype C0011847|diabetes
Sentences 36
PubMedID- 24690487 Among these, alström syndrome (alms; omim #203800) is an autosomal recessive multi-systemic disorder characterized by cone rod-dystrophy resulting in blindness in early childhood, progressive hearing impairment, infantile or adolescent onset dilated cardiomyopathy, metabolic defects leading to hyperinsulinemia, hypertriglyceridaemia, type-2-diabetes mellitus, and obesity[3], and progressive pulmonary, hepatic and renal dysfunction[4].
PubMedID- 24389129 Ang 1-7 represents a promising therapy for diabetic cardiomyopathy associated with type 2 diabetes mellitus.
PubMedID- 23223177 cardiomyopathy in diabetes is characterized by decreased muscle mass, interstitial fibrosis, and impaired ventricular function.
PubMedID- 23473489 diabetes is independently associated with a specific cardiomyopathy, characterized by impaired cardiac muscle relaxation and force development.
PubMedID- 23543004 Hiv infection, diabetes mellitus, history of ischemic cardiomyopathy, and undergoing percutaneous coronary intervention were associated in univariate analysis with occurrence of heart failure.
PubMedID- 25889404 The predominant feature in cardiomyopathy associated with diabetes, metabolic syndrome and ir seems to be the left ventricular diastolic dysfunction as shown in the present study and indicated in previous works [18,19].
PubMedID- 24083804 Development of a cardiomyopathy in diabetes mellitus is independent of traditional risk factors, with no clinical trials targeting specific therapeutic interventions.
PubMedID- 20809935 Currently, several clinical trials using pfd for various diseases have been completed; these include studies on pulmonary fibrosis associated with hermansk-pudlak syndrome, focal segmental glomerulosclerosis, idiopathic pulmonary fibrosis, hypertrophic cardiomyopathy, kidney disease in patients with diabetes, neurofibromatosis type 1, plexiform neurofibromas, and fibrosis caused by radiation therapy for cancer.
PubMedID- 21842146 Multiple studies have suggested that diabetes is associated with a cardiomyopathy characterized by diastolic abnormalities [26, 27••] and higher chamber stiffness, independent of hypertension and cad [25, 28•].
PubMedID- 24416343 Accordingly, we hypothesized that type 2 diabetes will lead to cardiomyopathy only in the presence of co-morbid factors such as hypertension.
PubMedID- 21897899 This study was taken upto find outthe prevalence of diabetic cardiomyopathy in patients with diabetes mellitus in manipur and its correlation with different parameters like obesity, blood pressure, lipids, duration of diabetes, and glycemic control.
PubMedID- 24614171 Many studies have shown that mitochondrial biogenesis and function are impaired in lipotoxic cardiomyopathy associated with obesity and diabetes [23], and that mitochondrial dysfunction is linked to cardiac dysfunction [24].
PubMedID- 22300387 Recent evidence suggests that cardiac diseases such as hypertension, coronary artery disease, congestive heart failure, and diabetic cardiomyopathy are associated with diabetes and hyperglycemia.
PubMedID- 20467928 This review focuses on the mechanistic approach to understand the molecular basis of diabetic cardiomyopathy in patients with type 2 diabetes mellitus.
PubMedID- 21525446 Although cardiomyopathy in patients with diabetes is increasingly recognized, the underlying mechanisms are still incompletely understood.
PubMedID- 21470409 In fact, clinical studies have demonstrated that diabetes, with consequent cardiomyopathy and cardiovascular neuropathy, is an independent risk factor for cardiovascular disease and is associated with a 2- to 4-fold increased risk of coronary heart disease [2].
PubMedID- 25936316 Immunoadsorption can improve cardiac function in transplant candidates with non-ischemic dilated cardiomyopathy associated with diabetes mellitus.
PubMedID- 22187379 diabetes is often associated with a specific cardiomyopathy characterized by alterations in systolic and diastolic function as well as microangiopathy.
PubMedID- 21492425 In addition, type 2 diabetes mellitus is associated with a cardiomyopathy characterised by left ventricular hypertrophy (lvh) and diastolic dysfunction [3].
PubMedID- 25657971 However, postmortem, experimental, and observational studies also provide evidence for a specific cardiomyopathy in diabetes, which may contribute to myocardial dysfunction in the absence of coronary artery atheroma.
PubMedID- 22166644 Effects of valsartan on diabetic cardiomyopathy in rats with type 2 diabetes mellitus.
PubMedID- 22621761 While diabetes leads to cardiomyopathy in later stages with hypocontractility and reduced serca activity [6], we have observed increased contractility in earlier stages of type 2 diabetes mellitus [7].
PubMedID- 23196711 Obesity-related diabetes mellitus leads to lipotoxic cardiomyopathy resulting in a form of cardiac dysfunction.
PubMedID- 21159162 Background: apoptosis is an early event involved in cardiomyopathy associated with diabetes mellitus.
PubMedID- 23961319 There is a growing body of evidence that diabetes mellitus leads to a specific cardiomyopathy apart from vascular disease and bring about high morbidity and mortality throughout the world.
PubMedID- 25671766 Thus, carbamylation and uremic cardiomyopathy are associated in patients with diabetes mellitus and kidney disease.
PubMedID- 20813091 A fetal dilated and hypertrophic cardiomyopathy associated with maternal gestational diabetes--a case report.
PubMedID- 21403831 Several models are available to study atherosclerosis and cardiomyopathy associated with diabetes, including apoe−/− and ldlr −/− mice in which type 1 diabetes is induced by streptozotocin or viral injection [33, 34].
PubMedID- 20811489 The diastolic dysfunction is most likely the result of the higher preponderance of pre-existing hypertension/raised blood pressure and diabetes in patient with ms. hypertensive cardiomyopathy in its various stages has a predominant impact on diastolic rather than systolic function.
PubMedID- 23320804 Additionally, the absence of cardiomyopathy in diabetes has been reported to be accompanied by increased glutathione s-transferase activity in rat hearts[78].
PubMedID- 24621572 Assuming that the development of cardiomyopathy in patients with diabetes may take years and furthermore be accelerated by the co-existence of arterial hypertension and coronary artery disease [26], our study population might be too young to detect cardiac abnormalities.
PubMedID- 23049681 To determine the therapeutic effects of aps treatment on cardiac dysfunction in lipotoxic cardiomyopathy with or without diabetes, echocardiography was performed on both db/db mice and mhc-pparα mice with or without aps treatment.
PubMedID- 23930867 Objective: to determine the frequency of diabetic cardiomyopathy among patients with type-2 diabetes presenting with overt heart failure.
PubMedID- 23556005 In the context of diabetic cardiomyopathy, metabolic byproducts associated with diabetes, such as ros and oxidized lipoproteins, may trigger mast cell activation [11], but the exact mechanism is unclear because mast cells are sensitive to many environmental stressors and those specific to diabetes have not been identified.
PubMedID- 20414371 To date, the mcp-1 –2518 a>g polymorphism has been associated with coronary artery disease, nonfamilial idiopathic dilated cardiomyopathy, carotid atherosclerosis in patients with type 2 diabetes, myocardial infarction, ischemic heart disease, and hypertension [33–38].
PubMedID- 26185602 Independent of hypertension and coronary artery disease, diabetes is associated with a specific cardiomyopathy, known as diabetic cardiomyopathy (dcm).

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