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PedAM

Pediatric Disease Annotations & Medicines




Disease carcinoid syndrome
Phenotype C0011991|diarrhea
Sentences 11
PubMedID- 25032009 Adverse effects include nausea and diarrhea, and a risk of serotonin syndrome exists if used concurrently with certain groups of antidepressants (iruela, minquez, merino, & monedero, 1993).
PubMedID- 25012985 We assessed the safety and efficacy of telotristat etiprate, an oral serotonin synthesis inhibitor, in patients with diarrhea associated with carcinoid syndrome.
PubMedID- 22518322 Lung carcinoids rarely produce serotonin, but may instead secrete histamine causing an atypical carcinoid syndrome with generalized flushing, diarrhea, periorbital oedema, lacrimation and asthma.
PubMedID- 24714698 By this mechanism, somatostatin analogs prevent spontaneous and provoked flushing and secretory diarrhea in patients with carcinoid syndrome.
PubMedID- 24213230 Somatostatin analogues effectively inhibit hormonal secretion and ameliorate flushing and diarrhea in about 75% of patients with carcinoid syndrome (40%–100%) [7].
PubMedID- 25889934 Only one patient had symptoms of carcinoid syndrome with spurious diarrhea and flushing.
PubMedID- 23118529 The classical carcinoid syndrome, with flushing, diarrhea, and right-sided valvular heart disease, is caused by secretion of serotonin from a metastatic ileal carcinoid tumor.
PubMedID- 25323816 The case highlights the importance of considering functional nets, especially carcinoid syndrome, in patients with chronic unresolving diarrhea, since early diagnosis allows for further treatment options that can prolong survival.
PubMedID- 21678105 The classical carcinoid syndrome with flush, diarrhea and cardiac strain is observed only in 20-30% of patients.
PubMedID- 25636046 Context: carcinoid syndrome (cs) is associated with elevated serotonin, diarrhea, flushing, and increased risk of valvular heart disease.
PubMedID- 21623673 Background: diarrhea is part of the carcinoid syndrome and a significant clinical problem in neuroendocrine tumor (net) patients.

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