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PedAM

Pediatric Disease Annotations & Medicines




Disease c syndrome
Phenotype C0033687|proteinuria
Sentences 61
PubMedID- 24798567 Rituximab, a chimeric monoclonal antibody against the cd20 antigen on b cells, safely reduced proteinuria in patients with nephrotic syndrome secondary to membranous nephropathy, minimal change disease, or focal segmental glomerulosclerosis.
PubMedID- 25558821 Immunosuppressive agents should be used for patients who suffer from refractory proteinuria or complications associated with nephrotic syndrome.
PubMedID- 25688242 Lupus nephritis is a frequent and potentially serious complication among patient with systemic lupus erythematosus whose clinical manifestations are varied being the most common manifestations proteinuria (commonly leading to nephrotic syndrome), microscopic hematuria, and reduced gfr.
PubMedID- 21132650 A 47-year-old woman was referred to our unit for evaluation of proteinuria associated with nephrotic syndrome.
PubMedID- 23670304 Podocyte loss correlated with lower selectivity of proteinuria in patients with minimal change nephrotic syndrome and focal segmental glomerulosclerosis (r = -0.90; p < 0.001).
PubMedID- 23759297 Results: all patients presented with proteinuria, associated with nephrotic syndrome (41%), hematuria (73%), and hypertension (70%).
PubMedID- 23295293 Nephropathy in fs consists in nephrotic syndrome (ns) with proteinuria that begins early in childhood and progressively increases with age, mainly due to nonspecific focal and segmental glomerular sclerosis (fsgs).
PubMedID- 21462608 The nephritic syndrome is associated with hematuria and proteinuria and abnormal kidney function and carries poorer prognosis and is typically associated with hypertension.
PubMedID- 26203254 Renal toxicity is an uncommon ae of all nsaids, and risk is elevated in those who have preexisting severe hepatic or renal dysfunction, nephrotic syndrome with high-level proteinuria, older age, diabetes, hypertension, congestive heart failure, or dehydration.
PubMedID- 23479095 Presenting features comprise any of the following: proteinuria (sometimes with the nephrotic syndrome), haematuria, hypertension and renal failure.
PubMedID- 23476687 Mutations in the podocin gene cause severe structural podocyte alterations and massive proteinuria leading to nephrotic syndrome [25].
PubMedID- 23559294 Background: collapsing glomerulopathy is a cause of nephrotic syndrome with massive proteinuria secondary to podocyte proliferation and glomerular collapse.
PubMedID- 26395882 In the first year of life, 66 % of the patients suffering from hypoalbuminemia and severe proteinuria are diagnosed with genetic nephrotic syndrome (gns) [1].
PubMedID- 21151138 Therefore, treatment with sialic acid precursors constitute a potential therapeutic tool to reduce proteinuria in some forms of nephrotic syndrome.
PubMedID- 23433013 Smoking, a bmi of ≥25, systolic bp of ≥110 mmhg, pulse pressure of ≥40 mmhg, and the presence of metabolic syndrome were associated with proteinuria in the univariate analysis.
PubMedID- 21534236 Clinically, lg is characterized by proteinuria generally associated with nephrotic syndrome and progressive renal insufficiency.
PubMedID- 26054711 Serum half-life of rtx can be extremely short, partly due to excessive urinary losses in therapy-resistant nephrotic syndrome with non-selective proteinuria, as seen in our patient.
PubMedID- 22909024 They are characterized by heavy proteinuria, with nephrotic syndrome and impaired renal function in half of the patients.
PubMedID- 23006339 In september 2010, her nephrotic syndrome returned with proteinuria (9.5 g/d), anasarca (11.3 kg weight gain), hyperlipidemia (total cholesterol 332 mg/dl, ldl 229 mg/dl, triglycerides 270 mg/dl), and a cr of 1.9 mg/dl.
PubMedID- 24527245 These cytokine and inflammatory mediators are thought to damage the glomerular foot processes, leading to proteinuria and other sequelae of nephrotic syndrome [8].
PubMedID- 23434736 The proband presented at 3 weeks of age with generalised oedema and was found to have severe hypoalbuminaemia and proteinuria and was diagnosed with congenital nephrotic syndrome.
PubMedID- 22661128 Because of a lack of ultrastructural detail (the electron microscopy was not invented until 50 years later) and limited by only a superficial insight in renal inflammatory processes, the authors failed to recognize the glomerulus as the origin of proteinuria in patients with the nephrotic syndrome and placed too much emphasis on tubular reabsorption patterns coined lipoid nephrosis.
PubMedID- 25834748 At the age of 35, he had proteinuria and was diagnosed with nephrotic syndrome and kidney injury.
PubMedID- 23275781 In the following months, the serum creatinine increased up to 2.2–2.4 mg/dl (egfr 27.5 ml/min/1.73 m2), blood pressure control continued to be poor, and there was a persistence of edema and nephrotic syndrome with proteinuria of 8 g/day.
PubMedID- 21844386 Mice developed a nephrotic syndrome with severe edema, proteinuria, hypoalbuminemia, and elevated cholesterol and triglycerides.
PubMedID- 26551740 Focal segmental glomerulosclerosis (fsgs) is a pathologic entity that is a common cause of nephrotic syndrome with severe proteinuria in both adults and children.
PubMedID- 22078716 Hypo-albuminemia accompanied by significant proteinuria is a component of the nephrotic syndrome that may accompany active lupus renal disease.
PubMedID- 23569546 Gemcitabine treatment may be associated with proteinuria to the extent of nephrotic syndrome.
PubMedID- 21904677 The development of nephrotic-range proteinuria, without full nephrotic syndrome, is consistent with the role of b4 as a minor podocyte integrin.
PubMedID- 19773419 Recurrence of nephrotic-range proteinuria in patients with idiopathic nephrotic syndrome (ins) and focal and segmental glomerulosclerosis (fsgs) on native kidneys is associated with poor graft survival.
PubMedID- 25815169 Rapidly progressive glomerulonephritis (rpgn) is clinical syndrome defined by the rapid loss of renal function, accompanied by features of a nephritic syndrome with proteinuria, glomerular haematuria and often oliguria.
PubMedID- 24886259 Mutations in the podocin gene cause severe structural podocyte alterations and massive proteinuria leading to nephrotic syndrome [22].
PubMedID- 20419132 Mutations of the nephrin gene lead to congenital nephrotic syndrome with proteinuria and renal failure [12].
PubMedID- 20649959 As previously reported [3,9], a single injection of pan (150 mg/kg body wt) to rats induced a marked nephrotic syndrome with severe proteinuria (~10 g/mmol creatinine) and decreased sodium excretion (< 5 mmol/mmol creatinine) (figure 4a).
PubMedID- 26447100 Background: proteinuria leading to nephrotic syndrome is a rare adverse event arising from treatment with bevacizumab.
PubMedID- 23162265 The limited evidence suggested that dfz appeared to be equally effective in inducing remission or decreasing proteinuria in patients with nephrotic syndrome.
PubMedID- 24282415 Due to persistent activation of the chronic inflammatory process, whether clinically manifested orsubclinically, excess saa is deposited in the form of fibrils in various organs, particularly the kidneys, with the consequent progressive development of severe proteinuria, leading to nephrotic syndrome and kidney failure.
PubMedID- 23197960 In conclusion, bilateral rae is an alternative, effective, rapid, and safe procedure for the treatment of heavy proteinuria with nephrotic syndrome.
PubMedID- 25886386 Studies also showed that as-iv can attenuate podocyte injury and ameliorate proteinuria in adults with idiopathic nephrotic syndrome [16].
PubMedID- 24294005 At the time of biopsy, six (75%) of them had nephrotic syndrome with mean proteinuria of 3.8 ± 2.24 g/day.
PubMedID- 25874088 Here we report an association between collapsing glomerulopathy and an acute ebv syndrome, manifesting itself clinically as nephrotic syndrome with massive proteinuria, hypoalbuminemia, anasarca and hypercholesterolemia.
PubMedID- 21403411 Although a moderate degree of proteinuria is common in patients with igan, nephrotic syndrome is considered uncommon in these patients.3 the course of igan is variable, and 15% to 40% of patients progress to end-stage renal disease over a period of 10 to 20 years.4 the pathogenesis of igan is complex and not completely understood.
PubMedID- 24611049 In the systemic loop, it binds to glomerular endothelial αvβ5 integrin and reduces proteinuria, the principal driver of nephrotic syndrome.
PubMedID- 22543358 Similarly, podocyte-specific (p)rr knock-out mice are born at mendelian rates, but, early in life, develop nephritic syndrome, with severe proteinuria and albuminuria due to progressive glomerular sclerosis, and die within 2–4 weeks of renal failure [68, 79, 84].
PubMedID- 21497573 Renal manifestations are frequent, mostly characterized by heavy proteinuria, with nephrotic syndrome and renal failure in more than half of the patients at diagnosis.
PubMedID- 24860853 Although sirolimus is not generally thought to be nephrotoxic, it can be associated with proteinuria, which can lead to nephrotic syndrome and subsequent kidney injury (25).
PubMedID- 23782479 Haematuria and proteinuria and subsequent development of nephrotic syndrome and chronic kidney disease (ckd) represent the commonest manifestations of hiv-related glomerular disease (table 1) [13].
PubMedID- 22461531 Results: initially, 95% of patients had nephrotic syndrome with proteinuria of 3-12 g per 24 hours, creatinine levels of 0.6-9.6 mg/dl, positive lupus serologies, and normal complement levels in 63%.
PubMedID- 24151517 In addition, metabolic syndrome has been associated with proteinuria and reduced gfr, suggesting a link to chronic kidney disease [93, 94].
PubMedID- 20483511 Diagnostic strategy relies on the clinical presentation: acute renal failure, chronic kidney disease, glomerular proteinuria with or without nephrotic syndrome, tubular proteinuria, hydroelectrolytic disorders.

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