PedAM
Pediatric Disease Annotations & Medicines
| Disease | c syndrome |
| Phenotype | C0028754|obesity |
| Sentences | 377 |
| PubMedID- 23734506 | [age dependence of metabolic syndrome association with obesity types among women]. |
| PubMedID- 22847239 | obesity is the hallmark of the metabolic syndrome and predisposes patients to the development of major chronic metabolic diseases including type 2 diabetes mellitus. |
| PubMedID- 22110764 | Metabolic syndrome (mets) is associated with glucose intolerance, obesity, ageing, elevated blood pressure and dyslipidaemia, all of which are risk factors associated with cardiovascular morbidity and mortality [1], [2]. |
| PubMedID- 22567052 | obesity, an integral component of the metabolic syndrome and type 2 diabetes, predisposes to the toxic effects of fatty acids on the myocardium and the additional detrimental effects of cytokines and angiotensin ii released by adipose tissue. |
| PubMedID- 24701367 | The metabolic syndrome commonly associated with obesity may lead to insulin resistance, rendering the body less adept at maximally utilizing glucose, a breakdown product of carbohydrates [175]. |
| PubMedID- 24269186 | In this study, we aim to examine the associations of obesity related loci with risk of metabolic syndrome (mets) in a children population from china. |
| PubMedID- 24052899 | Animals that are nutritionally deprived during the perinatal period show a thrifty phenotype, with catch-up growth supported largely by increased feed efficiency.1 under certain conditions, perinatal under-nutrition can lead to increased susceptibility to obesity and symptoms reminiscent of the metabolic syndrome, particularly when a high-fat diet is introduced postnatally.16,17 this effect appears to be dependent on the timing and magnitude of the post-natal leptin surge, as treating pups with leptin eliminates or attenuates many of these metabolic effects.17-20 our model of maternal food restriction did not result in any phenotypic changes to body weight, food intake, or body composition, and these measures were not differentially affected by caloric restriction. |
| PubMedID- 25048003 | The features of the metabolic syndrome, with accompanying obesity and changes in blood glucose levels, may represent a unique ’bath’ for brain circuitry associated with changes in both physiology and behavior that push us to recognize the intimate relationship between so-called medical and behavioral factors. |
| PubMedID- 26558034 | The latter must be viewed as a novel renal manifestation of insulin resistance in the context of metabolic syndrome with central obesity as its primary key feature. |
| PubMedID- 26042596 | Nafld is the hepatic manifestation of metabolic syndrome and is associated with obesity, type 2 diabetes mellitus, dyslipidemia, high blood pressure, insulin resistance and cardiovascular disease [1–3]. |
| PubMedID- 25995613 | The rest of the components of metabolic syndrome, including obesity, elevated triglycerides, low hdl, and fasting glucose, were seen in equal prevalence among diabetics with and without diabetic retinopathy and among diabetics with npdr and pdr (figure 1, tables 2 and 3). |
| PubMedID- 26469529 | obesity is associated with the metabolic syndrome. |
| PubMedID- 25134788 | Objective: non-alcoholic fatty liver disease (nafld) is closely linked to obesity and constitutes part of the metabolic syndrome, which have been associated with low serum vitamin d (vd). |
| PubMedID- 24815358 | Metabolic syndrome, including obesity, diabetes/insulin resistance, hypertension and dyslipidemia is a major threat for public health in the modern society. |
| PubMedID- 24904871 | Another study reported that hypothalamic obesity is associated with metabolic syndrome and cardiovascular morbidity without increased insulin sensitivity36). |
| PubMedID- 26378573 | H rats showed signs of metabolic syndrome leading to visceral obesity with hypertension, glucose intolerance, cardiovascular remodelling and nonalcoholic fatty liver disease. |
| PubMedID- 20562852 | For instance, our previous studies in clockδ19/δ19 mutant mice showed that these mice are susceptible to obesity and certain features of metabolic syndrome including steatosis, adipose hypertrophy, and hyperlipidemia, due to primary defects within both hypothalamus (decreased anorexigenic peptidergic signaling), and also within liver. |
| PubMedID- PMC3559529 | obesity in the absence of diabetes or metabolic syndrome is associated with significant myocardial triglyceride deposition and impaired strain in adults and children. |
| PubMedID- 24224148 | Pufas are used for metabolic syndrome related with obesity or diabetes. |
| PubMedID- 22332072 | obesity is associated with the metabolic syndrome, a significant risk factor for developing type 2 diabetes and cardiovascular diseases. |
| PubMedID- 24554764 | Kdm3a knockdown leads to immotile round-headed spermatozoa (globozoospermia) and metabolic syndrome associated with obesity and diabetes (okada et al., 2007; inagaki et al., 2009; tateishi et al., 2009; liu et al., 2010) through the regulation of genes involved in histone replacement during spermatogenesis and regulation of gene expression during adipogenesis. |
| PubMedID- 24511516 | Diabetes, hyperlipidemia and obesity form the basis of the metabolic syndrome; it was shown to be an independent predictor of poor outcomes in heart transplant recipients. |
| PubMedID- 25875942 | Non-alcoholic fatty liver disease (nafld) is the most common cause of hepatic disease in western civilization [1] and is considered as a hepatic manifestation of a metabolic syndrome strongly associated with dyslipidemia, obesity, hypertension and insulin resistance[2]. |
| PubMedID- 25679397 | Effects of metabolic syndrome with or without obesity on outcomes after coronary artery bypass graft. |
| PubMedID- 20490316 | This corticosterone index could be correlated with an increase in both obesity and symptoms of metabolic syndrome [43]. |
| PubMedID- 25888859 | Nash is considered the hepatic manifestation of the metabolic syndrome and is associated with central obesity, insulin resistance, diabetes, essential hypertension, and dyslipidemia [17,18]. |
| PubMedID- 26255568 | Metabolic syndrome, abdominal obesity and hyperuricemia in schizophrenia: results from the face-sz cohort. |
| PubMedID- 26413119 | obesity leads to metabolic syndrome and insulin resistance and causes type ii diabetes, hypertension, and high cholesterol. |
| PubMedID- 20338978 | Earlier studies showed that sedentary behaviour is positively associated with coronary heart disease risk factors, obesity and development of the metabolic syndrome [37]. |
| PubMedID- 26439630 | Over the last decades, increased obesity is associated with increased metabolic syndromes characterized by type-2-diabetes (t2d), cardiovascular diseases (cvd) or low-grade inflammation. |
| PubMedID- 22701354 | However, obesity is associated with metabolic syndrome characterized by alterations in glucose metabolism, lipids, and presence of hypertension [21]. |
| PubMedID- 21540583 | Background: hyperlipidemia and obesity are associated with metabolic syndrome and increased risk in developing diabetes and cardiovascular disease. |
| PubMedID- 26003803 | However, the pattern of disease initiation and development in the models used in these studies was not closely analogous to the clinical situation of metabolic syndrome in humans, with characteristics of obesity, insulin resistance and hypertension, inflammation, hyperlipidemia and type 2 diabetes mellitus. |
| PubMedID- 20549135 | Objective: in this study we compared the ability of this index to identify hypertension and metabolic syndrome with other obesity indexes (body mass index--bmi; waist circumference--wc; and waist-to-hip ratio - whr) by receiver operating characteristic (roc) curve analyses. |
| PubMedID- 21668294 | Whereas fatness alone endangers physiological performance of even simple tasks, the associated co-morbidity of obesity including metabolic syndrome in all its manifestations is a far more critical problem. |
| PubMedID- 22281657 | Central obesity is the cause of the metabolic syndrome. |
| PubMedID- 20023693 | obesity is frequently associated with metabolic syndrome, a disease state that includes glucose intolerance, insulin resistance, hypertension, hypertriglyceridemia, low level of high-density lipoprotein cholesterol (hdl-c), and type 2 diabetes mellitus (t2dm)1. |
| PubMedID- 25885910 | Overweight and obesity, the epicenter of the metabolic syndrome, are the most important risk factors for diabetes [4-6]. |
| PubMedID- 23936649 | Given the current obesity epidemic, the prevalence of both metabolic syndrome and osas is on the rise. |
| PubMedID- 24306159 | Sarcopenic obesity is closely associated with metabolic syndrome. |
| PubMedID- 24716901 | Childhood obesity is also associated with metabolic syndrome including hyperinsulinemia/insulin resistance, dyslipidemia, and hypertension. |
| PubMedID- 25340546 | Background: obesity and related diseases of the metabolic syndrome contribute to the major health problems in industrialized countries. |
| PubMedID- 20092995 | Obtusiloba should be evaluated as a potential complementary treatment option for obesity associated with the metabolic syndrome. |
| PubMedID- 20981493 | Lower testosterone levels were associated with central obesity- a strong component of a metabolic syndrome, and unsubstituted testosterone deficiency might be an important cardiovascular risk factor in patients with hypopituitarism. |
| PubMedID- 23922564 | Nafld in iranian population is associated with male gender, old age, obesity, and features of metabolic syndrome. |
| PubMedID- 22041985 | Childhood obesity and risk of the adult metabolic syndrome: a systematic review. |
| PubMedID- 25191546 | Hypertension is common in obesity(65,66) and a feature of the metabolic syndrome, and is also an established riskfactor for cvd(67). |
| PubMedID- 23016134 | One mechanism that may explain microbial-induced obesity associated with metabolic syndrome and t2d, is endotoxemia which is characterized by excess circulating lps which triggers systemic inflammation [81,82]. |
| PubMedID- 22359684 | Non-alcoholic fatty liver disease (nafld) is one of the metabolic syndrome components closely associated with obesity, a worldwide pandemic [1]. |
| PubMedID- 23799054 | Several epidemiological studies have shown an association between the gnb3 825t allele and other features of metabolic syndrome, including obesity, insulin resistance, changes in autonomic nervous function, and dyslipidemia. |