PedAM
Pediatric Disease Annotations & Medicines
| Disease | bronchiectasis |
| Phenotype | C0004623|bacterial infections |
| Sentences | 3 |
| PubMedID- 26542299 | Cystic fibrosis is a mono-genetic multi-system disease; however, respiratory manifestations cause the main morbidity and mortality where chronic bacterial infections lead to bronchiectasis and ultimately respiratory failure. |
| PubMedID- 21295205 | As regards the latter, there is an acknowledged link between bronchiectasis and hiv-infection7,21–23 with recurrent bacterial infections7,23 or hiv-infection per se, believed to play an aetiological role.22 however, with respect to bronchiectasis specifically, it should be noted that chest radiographic diagnosis is not straightforward, even for experienced observers: the lower sensitivity of chest radiography (particularly for mild disease) and the notoriously non-specific radiographic appearances are important limitations.24–26 again, in this regard, hrct is likely to play a key role in future studies to define the morphological basis of chronic lung disease in this group of patients. |
| PubMedID- 22408675 | A 14-year-old adolescent boy, a known case of common variable immunodeficiency (cvid) – the diagnosis was based on persistent low levels of immunoglobulin g (igg), decreased cd4: cd8 t-cell ratio, and recurrent bacterial infections with bilateral bronchiectasis – was on regular monthly infusions of ivig (dose 400 mg/kg) for the past 3 years in our unit. |
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