PedAM
Pediatric Disease Annotations & Medicines
| Disease | breast cancer |
| Phenotype | C0220650|brain metastasis |
| Sentences | 53 |
| PubMedID- 20308667 | Nomogram to predict subsequent brain metastasis in patients with metastatic breast cancer. |
| PubMedID- 23361272 | Background: to evaluate the factors that have an impact on the development of brain metastasis in patients with breast cancer. |
| PubMedID- 24811334 | The presence of ctcs in cerebrospinal fluid (csf) has also been validated for breast cancer patients with brain metastasis, and can serve potentially as an early marker for the involvement of brain as a secondary site [6]. |
| PubMedID- 24013510 | Circulating tumor cells and brain metastasis outcome in patients with her2-positive breast cancer: the landscape trial. |
| PubMedID- 25032884 | Chemotherapy and biological treatment options in breast cancer patients with brain metastasis: an update. |
| PubMedID- 25060327 | Distinct mr imaging features of triple-negative breast cancer with brain metastasis. |
| PubMedID- 25743811 | This systematic review aimed to summarize the role of her2 in brain metastasis in patients with breast cancer. |
| PubMedID- 22304337 | Burden of breast cancer with brain metastasis: a french national hospital database analysis. |
| PubMedID- 23743596 | Systemic treatment after whole-brain radiotherapy may improve survival in rpa class ii/iii breast cancer patients with brain metastasis. |
| PubMedID- 23344048 | Chemokines seem to be important in the brain metastasis formation of breast cancer cells as well, since the cxcr4/sdf1 signaling pathway was shown to have a decisive role in the migration of breast cancer cells through brain endothelial monolayers [99]. |
| PubMedID- 26516313 | In additions, mir-7 also can inhibit brain metastasis of breast cancer and the self-renewal capacity of breast cancer stem-like cells by regulating the expression of krüppel-like factor4 (klf4) [24]. |
| PubMedID- 25893380 | Mir-10b was particularly high in breast cancers with brain metastasis, compared to breast cancers that did not metastasize. |
| PubMedID- 25963555 | A pdx line established from a brain metastasis of a her2-positive breast cancer showed strong membranous positivity (3+) for her2, and weak dispersed positivity for er and pgr, and therefore shared the same characteristics as the engrafted tumor (fig. |
| PubMedID- 24740972 | The combination of weekly trastuzumab plus vinorelbine may be preferable regimen in her-2 positive breast cancer patients with brain metastasis. |
| PubMedID- 23400960 | Independent risk factors for brain metastasis in patients with primary breast cancer were: being younger than 35 years old at the time of diagnosis, having four or more metastatic axillary nodes, being estrogen receptor-negative, and with 24 months of metastasis-free survival. |
| PubMedID- 23826254 | The prognosis of breast cancer patients with brain metastasis is generally poor and the survival of the patients ranges from 3–5 months [56]–[58]. |
| PubMedID- 25285241 | In a series of over 3,000 patients with brain metastasis arising from breast cancer treated from 1989 to 2006, multivariate analysis indicated that triple negative status was the greatest risk factor for the development of cerebral metastasis (odds ratio=4.16; p<0.001), above that of her2 positive status (or=3.43; p=0.005) [21]. |
| PubMedID- 23954201 | The number of involved extracranial organs: a new predictor of survival in breast cancer patients with brain metastasis. |
| PubMedID- 23267980 | [a long-surviving case of her2-positive breast cancer with brain metastasis treated by multidisciplinary therapy]. |
| PubMedID- 23591844 | Currently, survival of breast cancer patients with brain metastasis ranges from 2 to 16 months. |
| PubMedID- 21656328 | A univariate analysis and cox proportional hazards model were developed to identify factors influencing survival after brain metastasis in patients with triple-negative breast cancer. |
| PubMedID- 24586742 | In this study we analyzed the specific risk of brain metastasis associated with different breast cancer subtype in several age groups. |
| PubMedID- 25714030 | S. typhimurium a1-r also greatly inhibited bone and brain metastasis of breast cancer in orthotopic mouse models [20, 21]. |
| PubMedID- 23335064 | Purpose: in this study, we investigated the effect of lapatinib plus capecitabine treatment in her2-positive breast cancer patients with brain metastasis. |
| PubMedID- 26267412 | Aim: we aimed to assess the survival benefit of epidermal growth factor receptor 2 (her2)-positive breast cancer patients with brain metastasis (bm) after whole-brain radiotherapy (wbrt) in combination with systemic treatments, especially anti-her2 therapy. |
| PubMedID- 24137472 | The other case was of an isolated brain metastasis in a patient with breast cancer nine years after the initial therapy (13). |
| PubMedID- 22908046 | For example, in the 231-br brain metastasis model of the human breast cancer cell line mda-mb-231, palmieri et al. |
| PubMedID- 24294457 | The incidence of brain metastasis in patients with primary breast cancer is reported to be between 5% and 20% and the rate is increasing1). |
| PubMedID- 25659578 | The median survival time of breast cancer patients with brain metastasis is less than 6 months, and even a small metastatic lesion often causes severe neurological disabilities. |
| PubMedID- 26400100 | brain metastasis of breast cancer is a severe clinical problem that strongly affects patients’ quality of life. |
| PubMedID- 23495140 | Kaplan–meier analysis for brain metastasis-free survival of 710 breast cancer patients in geo data bases (gse12276, gse2034, gse2603, gse5327 and gse14020). |
| PubMedID- 25756607 | brain metastasis (bm) in patients with breast cancer is a catastrophic event that results in poor prognosis. |
| PubMedID- 26098772 | Additionally, we analyzed a subset of primary breast cancer patients, and certain patients with brain metastasis of lung and breast cancer and found high csf-1r, csf-1 and/or il-34 expression, respectively. |
| PubMedID- PMC3248131 | Interestingly, in a recent report comparing the expression profile of primary breast cancers with unlinked brain metastasis, hk2 was found to be consistently up-regulated in the brain metastatic tumors but not the primary breast cancers. |
| PubMedID- 23569464 | Additional studies using cancer-cell targeted nanoparticles warrant investigations given the potential improvement in anticancer therapy against brain metastasis of breast cancer afforded by the synergistic effect of s1p with typical cancer chemotherapeutic drugs. |
| PubMedID- 24278371 | In fact hbegf is a gene known to have a role in brain metastasis of breast cancer [13], while ereg is a gene known to be mediating lung metastasis of breast cancer [4]. |
| PubMedID- 19840953 | Materials and methods: the group of 222 breast cancer patients with brain metastasis was divided into three biological subgroups. |
| PubMedID- 23595625 | Celecoxib and anti-gr1 treatment may be useful for blockade of these processes, thereby preventing brain metastasis in patients with breast cancer. |
| PubMedID- 26216259 | Objective: brain metastasis occurs in 10-15% of metastatic breast cancer patients and is associated with poor prognosis. |
| PubMedID- 25715765 | brain metastasis affects one third of patients with her2-positive breast cancer after treatment with trastuzumab. |
| PubMedID- 22236677 | The incidence of brain metastasis in patients with metastatic breast cancer ranges from 14 to 16%.age, number of metastatic sites, short disease-free survival and molecular subtypes are associated with the occurrence of brain metastasis. |
| PubMedID- 25834608 | We conducted a retrospective review of breast cancer patients with brain metastasis after primary surgery. |
| PubMedID- 22082486 | In a series of 3000 breast cancer patients with brain metastasis [134], the tn status was the strongest risk factor for brain relapse. |
| PubMedID- 23578424 | Objective: to investigate the clinicopathological characteristics and prognosis in breast cancer with brain metastasis (bcbm). |
| PubMedID- 22915160 | We aimed to define the clinicopathologic characteristics of breast cancer (bc) patients with brain metastasis (bm) and to investigate the effect of these parameters on survival. |
| PubMedID- 26164063 | We report, the case of a patient suffering from breast cancer with brain metastasis in whom the biological documentation of the metastatic disease permitted to tailor the systemic treatment. |
| PubMedID- 22790050 | In our case of her2-positive breast cancer with brain metastasis that presented with hydrocephalus, vp shunting relieved the symptoms and improved the qol of the patient, enabling treatment with lapatinib+capecitabine to be continued. |
| PubMedID- 22839200 | A retrospective analysis of 126 metastatic breast cancer patients with brain metastasis revealed prolonged survival associated with hormone receptor-positive compared to hormone receptor-negative subtype in her2-positive disease when measured from the date of systemic recurrence (median, 27.4 months vs 20.9 months) or from brain metastasis (median, 9.2 months vs 5.0 months) [16]. |
| PubMedID- 25031923 | Thrombocytopenia due to chemotherapy can lead to intracranial hemorrhage.non–small cell lung cancer (nsclc) and breast cancer patients with brain metastasishave a high predisposition for spontaneous cerebral hemorrhage. |
| PubMedID- 24761771 | Reported median survival rates of breast cancer patients with brain metastasis are usually in the range of 3 to 8 months [9,14,16,17,32]. |
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