PedAM

Pediatric Disease Annotations & Medicines

Disease	breast cancer
Phenotype	C0028754\|adiposity
Sentences	14
PubMedID- 23762816	We examined associations between adiposity and risk of breast cancer defined by hormone receptor status in a population-based case-control study conducted from 1995–2004 in the san francisco bay area.
PubMedID- 22689088	Among post-menopausal women, however, both obesity and visceral adiposity increase the risk of breast cancer [10, 11].
PubMedID- 24118876	Other studies, largely conducted among ea women, have generally reported increased risk of postmenopausal breast cancer associated with central adiposity, mostly measured with whr [4], although there is some inconsistency across studies particularly for whr [6] and no association for premenopausal breast cancer [4].
PubMedID- 22583394	Introduction: associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (bmi) with hormone-receptor negative malignancies, and possible interactions by hormone replacement therapy (hrt) use.
PubMedID- 21278356	Among never users, but not among users of hormonal therapy, incidence rates for breast cancer increased with increasing adiposity (figure 5).
PubMedID- 26193782	Using cox regression analysis, we estimated multivariable hazard ratios (hrs) and 95% confidence intervals (95% cis) for breast cancer risk associated with adiposity measurements, considering tumor subtype and menopausal status.
PubMedID- 23991180	The woman weight gain and excess adiposity are positively associated with breast cancer in postmenopausal women and inversely associated in premenopausal women [47,48].
PubMedID- 22800711	The association of adiposity with breast cancer is complex.
PubMedID- 20848591	Whereas mammographic density and adiposity are positively associated with postmenopausal breast cancer risk, they are inversely associated with one another.
PubMedID- 22953181	In contrast, there is consistent epidemiological evidence and a clear dose-response relationship, with robust evidence for mechanisms operating in humans, indicating that greater body adiposity is associated with postmenopausal breast cancer risk (rr 1.50, 95% ci 1.50-1.60 per 2 kg/m2) [15,21].
PubMedID- 25834745	However, disruption of female sex steroid function, such as following menopause, hysterectomy, or breast cancer treatment, is associated with excess visceral adiposity [16].
PubMedID- 25250133	When central adiposity increases, the risk of breast cancer has increased in postmenopausal women particularly when there is a family history of breast cancer [75].
PubMedID- 24156623	Further, epidemiological studies have associated basal-like breast cancer with increased abdominal adiposity [83]; although hfd-e tumor-bearing animals were not obese, obesity was associated with hfd.
PubMedID- 20937135	However, the relationship of adiposity with breast cancer especially in postmenopausal women could be partially explained by the increases in endogenous estrogens [29], and not by a decrease in biovailable androgens.

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