PedAM
Pediatric Disease Annotations & Medicines
| Disease | autoimmune enteropathy |
| Phenotype | C0040100|thymoma |
| Sentences | 1 |
| PubMedID- 24872711 | Ttg is the known target in celiac disease, deaminating gliadin peptide, leading to increased presentation to t-cells, and thereby stimulating the immune system.10 some studies reported autoimmune enteropathy in association with thymoma, but there are few studies addressing the association of celiac disease and thymoma.15,16 also, association between aplastic anemia and celiac disease have rarely been reported, and it is supposed that this relation to share an underlying immune pathological mechanism that destroys tissue with t-cell mediation.13,14,17 it is important to know that a gluten-free diet is protective against the development of malignancy during celiac disease.13 immunophenotyping of peripheral blood t-cells expressing t-cell receptor γß discriminated celiac disease from autoimmune enteropathy, which commonly expresses t-cell receptor αβ.18 megakaryocytic hypoplasia has been reported after resection of a thymoma in previous studies,2,19 and the association of thymoma with pure red cell aplasia is well known.20 amegakaryocytic thrombocytopenia following thymoma may represent an early presentation of impending aplastic anemia, with the time interval between thymoma resection and development of aplastic anemia between 3 and 48 months.2,21 aplastic anemia may be related with active thymoma or with thymoma in remission.22 our case showed anemia and thrombocytopenia with megakaryocytic hypoplasia 2 weeks after thymectomy, presenting symptoms of aplastic anemia. |
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