PedAM
Pediatric Disease Annotations & Medicines
| Disease | arthropathy |
| Phenotype | C0001206|acromegaly |
| Sentences | 5 |
| PubMedID- 23008710 | The radiological appearance of arthropathy in acromegaly was mostly studied in small noncontrolled groups of patients with untreated and treated but active disease. |
| PubMedID- 20369240 | The arthropathy in acromegaly is the most frequent and important cause of morbidity and functional disability in acromegaly. |
| PubMedID- 20194043 | Conclusion: these findings accentuate the importance of recognition of the clinical manifestations of arthropathy in patients with acromegaly despite long-term disease control. |
| PubMedID- 22518126 | The pathogenesis of arthropathy in acromegaly is comprised of two mechanisms: initial endocrine elevated gh and igf-i levels promote growth of the articular cartilage and periarticular ligaments, subsequently leading to mechanical changes. |
| PubMedID- 21597975 | It is currently unknown whether gh and igf-1 control can reverse arthropathy in patients with acromegaly, however, improvement in signs and symptoms was demonstrated [45, 46]. |
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