PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0376358|prostate cancer |
| Sentences | 9 |
| PubMedID- 19854473 | Given the substantial role of hypoxia in prostate cancer development and treatment, this investigation focuses on the hypoxia inducible factor (hif-1alpha) pathway. |
| PubMedID- 24786921 | Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling. |
| PubMedID- 20407014 | Targeted knockdown of sept9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway. |
| PubMedID- 26205124 | Due to the role of hypoxia in prostate cancer progression, the key players in hypoxic adaptation and angiogenesis have been considered as drug targets for prostate cancer prevention and management8. |
| PubMedID- 23566222 | In addition, castration therapy was reported to decrease the synthesis of vascular growth factors, such as vegf and angiopoietins, and upregulate hypoxia, leading to apoptosis in prostate cancer [30]. |
| PubMedID- 22465832 | The aim of this study was to determine the effect of hypoxia in patients with prostate cancer treated with radiotherapy. |
| PubMedID- 21500193 | Treatment of metastatic rat and human prostate cancer cell lines with msea decreased hypoxia-inducible factor-1alpha (hif-1alpha) levels in a dose-dependent manner. |
| PubMedID- 22284032 | Conclusions: our data suggest that neoadjuvant castration decreases tumor cell hypoxia in prostate cancer, which may explain increased radiosensitivity after castration. |
| PubMedID- 21985947 | Conclusions: hypoxia in prostate cancer (low mean p/m po(2) ratio) significantly predicts for poor long-term biochemical outcome, suggesting that novel hypoxic strategies should be investigated. |
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