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PedAM

Pediatric Disease Annotations & Medicines




Disease anoxia
Phenotype C0159020|neonatal seizures
Sentences 4
PubMedID- 22567115 We used a rodent model of acute hypoxia-induced neonatal seizures that results in long term increases in neuronal excitability, seizure susceptibility, and spontaneous seizures, to determine how seizures alter mtor complex 1 (mtorc1) signaling.
PubMedID- 21366558 Significance: the rodent model of hypoxia-induced neonatal seizures leads to the development of epilepsy in later life, accompanied by increased mossy fiber sprouting.
PubMedID- 26341542 Effects of hypoxia-induced neonatal seizures on acute hippocampal injury and later-life seizure susceptibility and anxiety-related behavior in mice.
PubMedID- 22171027 hypoxia-induced neonatal seizures diminish silent synapses and long-term potentiation in hippocampal ca1 neurons.

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