PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0028754|obesity |
| Sentences | 15 |
| PubMedID- 23087670 | obesity is associated with liver tissue hypoxia, which may be further exacerbated by ih of osa (reinke et al., 2011a) resulting in hif activation. |
| PubMedID- 21147617 | Among disordered breathing during sleep, for clinical purposes, the following can be distinguished: isolated snoring, upper airway resistance syndrome (uars), apnea or hypopnea during sleep, and hypoxia associated with obesity (hypoventilation syndrome). |
| PubMedID- 22051061 | In addition, the disequilibrium between oxygen demand and supply in expanding adipose tissues in obesity can lead to local hypoxia, which might have a role in the pathogenesis of adipocyte dysfunction, altered adipokine expression, and adipose tissue inflammation [20]. |
| PubMedID- 23502673 | Dietary-induced obesity is often associated with local hypoxia and inflammatory response in adipose tissues. |
| PubMedID- 25745415 | We suggest that obesity-linked hypoxia may lead to similar alterations in brown adipocytes as in white fat cells - particularly changes in adipokine production, increased glucose uptake and lactate release, and insulin resistance. |
| PubMedID- 22964790 | Wat hypoxia in obesity has been observed in previous studies.48 those studies suggest that the increased wat hypoxia in young dio mice is important in initiating increased angiogenesis and the mild inflammation that contributes to the necessary tissue remodeling that allows c57 mice to gain more weight when exposed to a hfd. |
| PubMedID- 22005720 | Objective: obesity is associated with adipose tissue hypoxia, and is thought to be linked to the chronic low-grade inflammation of adipose tissue, although the precise mechanism has remained unclear. |
| PubMedID- 24307898 | It is well known that the increase of the adipocyte area and mass that occurs in obesity leads to hypoxia [59–61] (table 3). |
| PubMedID- 25852648 | In light of adipose tissue hypoxia associated with severe obesity (7, 10, 27), our study has led to a new disease mechanism underlying the etiology of obesity-associated cardiomyopathy. |
| PubMedID- 23274888 | It seems, therefore, that the question of at hypoxia in obesity would be best addressed by looking at functional consequences in terms of a “metabolic signature” of hypoxia. |
| PubMedID- 25964776 | A second argument that has been put forward to develop the concept of adipose tissue hypoxia in obesity is that the diameter of hypertrophic adipocytes in obesity exceeds the normal diffusion distance of oxygen across tissues (100–200 μm) (14). |
| PubMedID- 23555610 | It is tempting to speculate that the mechanical shear stress and loading of obesity interact with the relative hypoxia of low iron stores on bone to secrete fgf-23. |
| PubMedID- 23049707 | obesity is associated with tissue hypoxia and the up-regulation of hypoxia inducible factor 1 alpha (hif-1alpha). |
| PubMedID- 24564828 | Recent studies demonstrated that obesity is associated with adipose tissue hypoxia in humans and rodents [48-50]. |
| PubMedID- 23772224 | In obesity, expansion of adipose-tissue causes hypoxia and stress, leading to necrosis of adipocytes. |
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