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PedAM

Pediatric Disease Annotations & Medicines




Disease anoxia
Phenotype C0027819|neuroblastoma
Sentences 4
PubMedID- 25078098 We previously identified a 62-probe sets signature (nb-hypo) to identify tissue hypoxia in neuroblastoma tumors and showed that nb-hypo stratified neuroblastoma patients in good and poor outcome [1].
PubMedID- 26041997 N-myc triggers the apoptosis of neuroblastoma in hypoxia stress (rossler et al., 2001).
PubMedID- 21824412 A study from pahlman and colleagues has also shown that hypoxia in neuroblastoma cells can alter gene expression to that of a more immature phenotype.26 there are recently published data demonstrating this critical role of hypoxia in maintaining the stem-like fraction of cancer cells [27,4,28].
PubMedID- 20104230 A study from pahlman and colleagues (jogi et al, 2002) has also shown that hypoxia in neuroblastoma cells can alter gene expression to that of a more immature phenotype.

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