PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0025202|melanomas |
| Sentences | 1 |
| PubMedID- 21119596 | Another study presented compelling evidence of a requirement for a specific epigenetic environment for kit-dependent transformation, demonstrating that in some melanomas kit cooperates with a hypoxia-inducible factor (hif-1α) to activate the downstream ras/raf/mek/erk pathway, and that in the absence of hypoxia or exogenous expression of this factor, kit was unable to induce transformation of melanocytes (monsel et al., 2009). |
Page: 1