PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0025202|melanoma |
| Sentences | 4 |
| PubMedID- 20051782 | Glyceraldehyde-3-phosphate dehydrogenase expression is altered by hypoxia in melanoma cells and primary human melanocytes. |
| PubMedID- 24714813 | It has also been found thatnotch1 is a key effector of the oncogene akt and hypoxia in melanoma development, and itcan facilitate melanoma development by maintaining cell proliferation and protectingcells from stress-induced cell death (14).overexpression of notch1 can also increase the aggressiveness of primary melanoma cellsthrough upregulation of β-catenin or n-cadherin (15,16). |
| PubMedID- 24958263 | The mechanisms of metastases and proliferation are not fully understood, even though there is evidence that melanoma development is associated with hif-1 (hypoxia-inducible factor 1) [14,15,16]. |
| PubMedID- 20934767 | Quantitative assessment of hypoxia in melanoma xenografts by dynamic contrast-enhanced magnetic resonance imaging: intradermal versus intramuscular tumors. |
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