PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0024530|malaria |
| Sentences | 3 |
| PubMedID- 23683327 | Rosetting contributes to microvascular obstruction in severe malaria,4 leading to hypoxia, acidosis, organ dysfunction and death. |
| PubMedID- 20716170 | In severe malaria, the importance of tissue hypoxia is reflected in the consistent observation of elevated concentrations of lactate in plasma on admission, with an increased lactate:pyruvate ratio.19 degradation of hif-1α under normoxia and its stabilization in hypoxia constitutes a major cellular response during the transition from ambient to low oxygen tension. |
| PubMedID- 23459254 | The lack of evidence for malaria induced hypoxia represents a puzzle that must be solved because the existence of increased syncytial knotting in placentas exposed to plasmodium appears to suggest that hypoxic conditions do in fact occur. |
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