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PedAM

Pediatric Disease Annotations & Medicines




Disease anoxia
Phenotype C0022661|chronic kidney disease
Sentences 3
PubMedID- 22555252 Novel studies of their role in inflammation have identified that pericytes are not only major contributors to the activated matrix depositing myofibroblast populations seen in progressive renal fibrosis but perhaps even more importantly, the detachment of renal pericytes from the vasculature contributes to the microvasculature rarefaction and subsequent hypoxia associated with chronic kidney disease.
PubMedID- 23481058 Renal expression of hypoxia inducible factor-1alpha in patients with chronic kidney disease: a clinicopathologic study from nephrectomized kidneys.
PubMedID- 22200419 Because kidneys consume a large amount of oxygen and are relatively inefficient in oxygen uptake, they are susceptible to hypoxia, especially in patients with advanced chronic kidney disease accompanied by loss of peritubular capillaries.

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