PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0022116|ischemia |
| Sentences | 34 |
| PubMedID- 24386346 | An interruption in blood supply to the retina will cause tissue ischemia, which leads to hypoxia and a rapid failure of energy production, and subsequent cell apoptosis or necrosis [1]. |
| PubMedID- 20178616 | The major finding of the study is that cerebral ischemia associated with hypoxia caused derangement of the energy-related content of brain metabolites which was conspicuously more pronounced in the hippocampal than cortical areas. |
| PubMedID- 21076527 | Mcao-induced focal cerebral ischemia was associated with increases in hypoxia-inducible factor (hif)-1α, inducible nitric oxide synthase (inos), tumor necrosis factor (tnf)-α, and active caspase-3 expressions in ischemic regions. |
| PubMedID- 20838473 | It has been shown that certain stimuli such as ischemia, low doses of endotoxin and hypoxia can induce preconditioning-dependent protective responses (cadet and krasnova, 2009). |
| PubMedID- 24314014 | Various mechanisms have been implicated including nerve compression secondary to rhabdomyolysis, nerve ischemia due to hypoxia and direct nerve toxicity of carbon monoxide. |
| PubMedID- 20298534 | Compared to näive ischemic brains, in the ischemia-tolerant brains preconditioned with hypoxia, several genes were differentially upregulated. |
| PubMedID- 23814541 | ischemia usually coexists with hypoxia, although ischemia and hypoxia are characterized by distinct patterns of injury. |
| PubMedID- 26147889 | Interestingly, we observed that simulated ischemia (combination of low ph-solution and hypoxia) stopped beating activity of eht during the first 15 min without any recovery during reoxygenation (data not shown). |
| PubMedID- 22300539 | Mcao-induced focal cerebral ischemia was associated with increases in hypoxia-inducible factor (hif)-1alpha, tumor necrosis factor (tnf)-alpha, inducible nitric oxide synthase (inos), and active caspase-3 protein expressions in ischemic regions. |
| PubMedID- 21124131 | Background: following various types of plastic surgery, such as adipose grafting and flap elevation, adipose tissue undergoes ischemia, leading to hypoxia and nutrient depletion. |
| PubMedID- 23470865 | Several stresses, namely, ischemia due to endotoxin and/or hypoxia may be inducers of gene activation for the expression of the il-6, icam-1, and other cytokines [47, 48]. |
| PubMedID- 24505215 | Renal failure in weil’s disease is a common complication, and the pathological condition is primary ischemia with subsequent tissue hypoxia and renal tubular damage. |
| PubMedID- 26497763 | ischemia leads to hypoxia, which initiates a series of events primarily related to the activation of platelets and the release of vasoconstrictive mediators, which further restricts blood flow to the ischemic area. |
| PubMedID- 25379414 | Dti measures (axial, radial and mean diffusivity, and fractional anisotropy (fa)) were acquired at hyperacute (3 h), acute (1 and 2 d) and chronic (1 and 4 week) times after transient cerebral hypoxia with unilateral ischemia in neonatal rats. |
| PubMedID- 25788948 | Muscle injury results in ischemia leading to short-term local hypoxia, but there are conflicting reports on the role of hypoxia on the myogenic program in vivo and in vitro. |
| PubMedID- 25973335 | Vascular disrupting agents (vdas) have been proposed as an effective broad spectrum approach to cancer therapy, by inducing ischemia leading to hypoxia and cell death. |
| PubMedID- 20817946 | To test more rigorously the hypothesis that hypoxia resulting from ischemia causes cx43 internalization, we infected neonatal rat ventricular myocytes (nrvm) with a cx43-gfp chimera, which enabled us to investigate by means of confocal microscopy the effect of hypoxia (1% o2 for 5 h) on cx43 distribution in live cardiomyocytes. |
| PubMedID- 23540714 | Myocardial ischemia is associated with profound tissue hypoxia due to an imbalance in oxygen supply and demand, and studies of hypoxia-elicited adaptive responses during myocardial ischemia revealed a cardioprotective role for the signaling molecule adenosine. |
| PubMedID- 21286429 | Other causes of myocardial failure that are known include myocardial ischemia due to hypoxia, decreased blood flow in coronary artery due to decreased cardiac output, and direct myocardial depression by the substances in amniotic fluid such as endothelin. |
| PubMedID- 25468770 | Using an in vitro approach, we demonstrate that cultured astroglial and microglia directly respond to pufa n3 administration by preventing ischemia-induced increase of cyclooxygenase 2, hypoxia-inducible factor 1alpha, inducible nitric oxide synthase, and interleukin 1beta. |
| PubMedID- 23946687 | The most important case of these cardiovascular disorders is myocardial ischemia (mi), which leads to hypoxia, necrosis and apoptosis and to organ dysfunction [2]. |
| PubMedID- 21968517 | Relatively small amounts of hypoxia can lead to myocyte ischemia and potentially myocyte death, which could significantly affect the outcomes of this protocol. |
| PubMedID- 24400168 | Moreover, blood perfusion and pulmonary gas exchange are impaired, and the arterial partial pressure of oxygen decreases relative to the increased number of vge, resulting in hypoxia with subsequent cardiac ischemia and cell death (butler and hills 1985; vik et al. |
| PubMedID- 22431955 | Delay in securing the airway prolongs the period of hypoxia and can lead to cerebral ischemia and death. |
| PubMedID- 22272091 | [18] has shown that high-dose iso produces relative hypoxia leading to ischemia by excessive activation of β1-adrenergic receptors leading to increased inotropic, chronotropic and dromotropic effects. |
| PubMedID- 23365490 | Both epo and vegf respond to hypoxia [203] leading to ischemia-induced angiogenesis. |
| PubMedID- 23028788 | A. representative t2 weighted mri’s at 48 h post-ischemia in hypoxia acclimated, and control rats. |
| PubMedID- 22470498 | Treatment of mouse limb ischemia with an integrative hypoxia-responsive vector expressing the vascular endothelial growth factor gene. |
| PubMedID- 26347611 | This is usually followed by the development of secondary injury as a result of cerebral hypoxia with ischemia which leads to brain swelling and edema, activation of inflammation and blood-brain barrier leakage. |
| PubMedID- 21651821 | Showed that a high-dose of iso produced relative hypoxia leading to ischemia by excessive activation of β1-adrenergic receptors that in turn resulted in increased inotropic, chronotropic and dromotropic effects [20]. |
| PubMedID- 24757621 | The relationship between bone marrow activity and cardiovascular disorders can be related to red blood cell function in circulation and available oxygen and, hypoxia ,and subsequent lead to ischemia (7). |
| PubMedID- 24400235 | Vascular endothelial growth factor (vegf) receptor inhibitors act by blocking angiogenesis, resulting in tumor hypoxia with subsequent ischemia and cell death. |
| PubMedID- 22935705 | Solid tumors often outgrow the blood supply, resulting in ischemia, which is associated with hypoxia and nutrient insufficiency. |
| PubMedID- 22833743 | Severe ischemia induces hypoxia and glucose deprivation in brain tissue. |
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