PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0020542|pulmonary hypertension |
| Sentences | 47 |
| PubMedID- 20427574 | Pasmcs have been suggested to be particularly sensitive to oxygen availability and to be responsible for acute hypoxic vasoconstriction and the development of pulmonary hypertension due to chronic hypoxia (weir et al., 2005; aaronson et al., 2006; stenmark et al., 2006; gupte and wolin, 2008). |
| PubMedID- 21908592 | Nfatc3 is required for chronic hypoxia-induced pulmonary hypertension in adult and neonatal mice. |
| PubMedID- 21246034 | Background: the present study investigated whether changes in gene expression in the right ventricle following pulmonary hypertension can be attributed to hypoxia or pressure loading. |
| PubMedID- 21335523 | P53 gene deficiency promotes hypoxia-induced pulmonary hypertension and vascular remodeling in mice. |
| PubMedID- 25691949 | Results: we found that the thoracic epidural blockade significantly decreased chronic hypoxia-induced pulmonary hypertension and vascular remodeling in rats. |
| PubMedID- 24647044 | Megakaryocytic leukemia 1 (mkl1) regulates hypoxia induced pulmonary hypertension in rats. |
| PubMedID- 20532059 | In patients who concurrently have hypoxic pulmonary vasoconstriction (hpv) and pulmonary hypertension due to alveolar hypoxia, such as ards, no has been used as a supplemental treatment agent when hypoxemia is not resolved with oxygen supply and the appropriate mechanical ventilation. |
| PubMedID- 24024204 | It is widely believed that the pulmonary hypertension associated with chronic hypoxia is due more to vascular remodelling, hypervolaemia, polycythaemia, and increased blood viscosity rather than hpv per se. |
| PubMedID- 22280813 | Objectives: it was previously shown that dehydroepiandrosterone (dhea) reverses chronic hypoxia-induced pulmonary hypertension (ph) in rats, but whether dhea can improve the clinical and hemodynamic status of patients with ph associated to chronic obstructive pulmonary disease (ph-copd) has not been studied whereas it is a very severe poorly treated disease. |
| PubMedID- 21890893 | We demonstrate here that sirt1 is targeted in macrophages by chronic hypoxia, which is associated with pulmonary hypertension (hph) and chronic obstructive pulmonary disease (copd) and oxldl, a primary risk factor for atherosclerosis. |
| PubMedID- 20416876 | hypoxia-induced pulmonary hypertension (hph) has been shown to decrease extralobar pulmonary artery (pa) compliance in the absence of smooth muscle cell (smc) tone and to increase smc tone in peripheral pas. |
| PubMedID- 22837861 | [1213] pulmonary hypertension associated with chronic hypoxia has been directly linked to an imbalance between glycolysis, glucose oxidation, and fatty acid oxidation. |
| PubMedID- 26275708 | Treatment with su5416 modestly aggravated hypoxia-induced pulmonary hypertension, right ventricular hypertrophy, and pulmonary arterial vessel wall thickening in ettg mice in association with increased interleukin-6 expression in blood vessels. |
| PubMedID- 21926265 | Peroxisome proliferator-activated receptor (ppar) gamma activation attenuates hypoxia-induced pulmonary hypertension (ph) in mice. |
| PubMedID- 25745471 | pulmonary hypertension is associated with hypoxia and the formation of so-called plexiform lesions. |
| PubMedID- 24503951 | Clic4 gene deletion markedly attenuated the development of chronic hypoxia-induced pulmonary hypertension in mice. |
| PubMedID- 25941359 | First, we found that il-6 blockade by the monoclonal anti-il-6 receptor antibody, mr16-1, ameliorated hypoxia-induced pulmonary hypertension (hph) and prevented the hypoxia-induced accumulation of th17 cells and m2 macrophages in the lungs. |
| PubMedID- 20634361 | Although physiological responses to chronic hypoxia, including pulmonary hypertension and right ventricular hypertrophy, have been well described, the molecular mechanisms involved in cardiopulmonary adaptations are still not fully understood. |
| PubMedID- 21926264 | Pharmacological activation of peroxisome proliferator-activated receptor-gamma (ppar-gamma) has been shown to prevent hypoxia-induced pulmonary hypertension and vascular remodeling in rodent models, suggesting a vasoprotective effect of ppar-gamma under chronic hypoxic stress. |
| PubMedID- 25863249 | Mice with ec deletion of bmpr2 develop hypoxia-induced pulmonary hypertension that, in contrast to non-transgenic littermates, does not reverse upon reoxygenation and is associated with reduced pa microvessels and lung ec p53, pgc1alpha and tfam, regulators of mitochondrial biogenesis, and mitochondrial dna. |
| PubMedID- 23628900 | hypoxia-induced pulmonary hypertension (ph), which is characterized by vasoconstriction and subsequent structural remodeling of blood vessels, is an important event in chronic obstructive pulmonary disease patients and in people living at high altitudes. |
| PubMedID- 23152932 | Lack of bcr and abr promotes hypoxia-induced pulmonary hypertension in mice. |
| PubMedID- 20110569 | Dynamic changes in lung microrna profiles during the development of pulmonary hypertension due to chronic hypoxia and monocrotaline. |
| PubMedID- 21454803 | We previously found that deficiency of the sodium-hydrogen exchanger 1 (nhe1) gene prevented hypoxia-induced pulmonary hypertension and vascular remodeling in mice, which were accompanied by a significantly reduced proliferation of pulmonary artery smooth muscle cells (pasmcs), and which decreased the medial-wall thickness of pulmonary arteries. |
| PubMedID- 24135024 | The extent of hypoxia-induced pulmonary hypertension was reduced in rock2(+/-) mice and was enhanced in rock2-tg mice compared with respective littermates. |
| PubMedID- 24705723 | Structural and functional prevention of hypoxia-induced pulmonary hypertension by individualized exercise training in mice. |
| PubMedID- 22965765 | Patients with asthma develop pulmonary hypertension due to recurrent hypoxia and chronic inflammation, leading to right heart enlargement with ventricular hypertrophy. |
| PubMedID- 24858807 | Chronic hypoxia induced pulmonary hypertension, right ventricular hypertrophy, increased lung weight, and increased hematocrit levels in either genotype. |
| PubMedID- 20811560 | Areas of emphysema cause an increased pulmonary vascular resistance due to alveolar hypoxia leading to pulmonary hypertension [12]. |
| PubMedID- 20622120 | We demonstrated that rosiglitazone, a synthetic agonist of the peroxisome proliferator-activated receptor-gamma (ppargamma), attenuated hypoxia-induced pulmonary hypertension, vascular remodeling, nox4 induction, and reactive oxygen species generation in the mouse lung. |
| PubMedID- 25151896 | Results: chronic hypoxia induced pulmonary hypertension after 4 weeks.rvsp significantly increased both in hypoxic female and male groups (normoxic vs hypoxic: (23.40 +/- 0.16) vs (31.46 +/- 2.33) and (24.71 +/- 0.44) vs (33.66 +/- 1.38) mmhg (1 mmhg = 0.133 kpa), p = 0.029 and p < 0.001).however, there were no inter-group differences (p = 0.447). |
| PubMedID- 22518182 | If not recognized and managed, chronic hypoxia can lead to pulmonary hypertension and cor pulmonale. |
| PubMedID- 23625956 | Chronic hypoxia induces pulmonary hypertension in proportion to initial vasoconstriction. |
| PubMedID- 19520921 | Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model. |
| PubMedID- 20026772 | The therapeutic effect of nitrite on hypoxia-induced pulmonary hypertension was significantly reduced in the p21-knockout mouse; however, nitrite still reduced pressures and right ventricular pathological remodeling, indicating the existence of p21-independent effects as well. |
| PubMedID- 26502863 | Objective: rat models of hypobaric hypoxia-induced pulmonary hypertension are commonly used in studies of chronic mountain sickness, while there are few researches specially focusing on these rats model. |
| PubMedID- 22937913 | However brachycephalic dogs may be predisposed to pulmonary hypertension, due to chronic hypoxia, and dogs with pulmonary hypertension can have increased concentrations of ctni [40]. |
| PubMedID- 22194859 | Complement c3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. |
| PubMedID- 22523357 | Dehydroepiandrosterone (dhea) prevents chronic hypoxia-induced pulmonary hypertension and associated right ventricle dysfunction in rats. |
| PubMedID- 22371803 | Over-secretion of anp is correlated with hypoxia, which leads to pulmonary vasoconstriction, pulmonary hypertension, and right-heart overload [22, 23]. |
| PubMedID- 25956683 | hypoxia-induced pulmonary hypertension was associated with a marked increase in beta-catenin/cyclin d1 expression in lungs. |
| PubMedID- 22240915 | Levosimendan attenuates hypoxia-induced pulmonary hypertension in a porcine model. |
| PubMedID- 26493804 | In contrast, during global alveolar hypoxia, hpv leads to pulmonary hypertension. |
| PubMedID- 26564080 | The sequelae of visceral organ involvement include ischemic stroke, cerebral bacterial abscesses, intracranial hemorrhage, chronic hypoxia, dyspnea with exertion, pulmonary hypertension, high output heart failure, gastrointestinal bleeds and liver failure. |
| PubMedID- 24084215 | hypoxia-induced pulmonary hypertension is characterized by progressive remodeling of the pulmonary artery (pa) system and loss of the transcription factor, camp response element binding protein (creb) in pa smooth muscle cells (smcs). |
| PubMedID- 25647182 | Smc-specific knockout of mir-17 approximately 92 attenuated hypoxia-induced pulmonary hypertension (ph) in mice, whereas reconstitution of mir-17 approximately 92 restored hypoxia-induced ph in these mice. |
| PubMedID- 20441584 | Background and objective: chronic hypoxia induces pulmonary hypertension in mice. |
Page: 1