PedAM
Pediatric Disease Annotations & Medicines
| Disease | anoxia |
| Phenotype | C0017636|glioblastoma |
| Sentences | 9 |
| PubMedID- 23451042 | Idh1 mutation itself may not be sufficient to account for a general hif-1α-driven hypoxia in glioblastoma, as elevated hif-1α levels are usually confined to severely hypoxic areas of necrosis [22] such as palisades. |
| PubMedID- 24922660 | Background: intratumoural hypoxia is associated with chemoresistance in glioblastoma multiforme (gbm), a highly malignant brain tumour. |
| PubMedID- 20623734 | Treatment of t98g glioblastoma cells with hypoxia mimetic cobalt chloride, which promotes hif-α stabilization (maxwell et al, 1999), sensitized t98g cells to emcv virulence (supporting information fig 5). |
| PubMedID- 21682571 | Further studies should explore relative hypoxia in glioblastoma and the potential therapeutic gains that can be achieved by lessening hypoxia during delivery of adjuvant treatment. |
| PubMedID- 21084864 | These observations link aeg-1 overexpression in glioblastoma with hypoxia and glucose deprivation, and targeting these physiological pathways may lead to therapeutic advances in the treatment of glioblastoma in the future. |
| PubMedID- 22719241 | [27], used ib models to characterise the role of hypoxia in glioblastoma, showing that reduced oxygen levels may down-regulate cell-cell adhesion, leading to increased motility. |
| PubMedID- 24457964 | glioblastoma cells incubated with il-1β in hypoxia showed more fluorescent-labeled fragmented dna (figure 5a). |
| PubMedID- 21179202 | Our first experiments tested the effect of zinc on hif-1-responsive vegf-luc activity in human u373mg glioblastoma cells treated with hypoxia (2% o2 or cobalt chloride to mimic hypoxia). |
| PubMedID- 24607407 | In human glioblastoma multiforme, expression of cd44 correlated with hypoxia-induced gene signatures and poor survival. |
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